119067-99-1Relevant academic research and scientific papers
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents
Rowland, Rhianna J.,Chen, Yurong,Breen, Imogen,Wu, Liang,Offen, Wendy A.,Beenakker, Thomas J.,Su, Qin,van den Nieuwendijk, Adrianus M. C. H.,Aerts, Johannes M. F. G.,Artola, Marta,Overkleeft, Herman S.,Davies, Gideon J.
supporting information, p. 16377 - 16388 (2021/11/03)
Gaucher disease (GD) is a lysosomal storage disorder caused by inherited deficiencies in β-glucocerebrosidase (GBA). Current treatments require rapid disease diagnosis and a means of monitoring therapeutic efficacy, both of which may be supported by the u
Synthesis and evaluation of hydroxymethylaminocyclitols as glycosidase inhibitors
Trapero, Ana,Egido-Gabás, Meritxell,Bujons, Jordi,Llebaria, Amadeu
, p. 3512 - 3529 (2015/04/14)
Four series of C7N aminocyclitol analogues of glucose were synthesized by stereocontrolled epoxide opening of hydroxyl protected forms of the cyclohexane epoxides cyclophellitol and 1,6-epi-cyclophellitol. The resulting hydroxymethyl substitute
Synthesis of novel cyano-cyclitols and their stereoselective biotransformation catalyzed by Rhodococcus erythropolis A4
D'Antona, Nicola,Nicolosi, Giovanni,Morrone, Raffaele,Kubac, David,Kaplan, Ondrej,Martinkova, Ludmila
experimental part, p. 695 - 702 (2010/08/03)
A variety of novel cyano-cyclitols possessing complex stereochemistry have been synthesized. These compounds were subjected to the biocatalyzed hydrolysis of their nitrile groups. The bacterial strain Rhodococcus erythropolis A4, expressing a nitrile hydr
A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms
D'Antona, Nicola,Morrone, Raffaele,Bovicelli, Paolo,Gambera, Giovanni,Kubac, David,Martinkova, Ludmila
experimental part, p. 2448 - 2454 (2011/02/22)
A new route to synthesize cyclophellitol and epi-cyclophellitol from racemic starting materials in enantiopure forms has been developed. The synthesis involves a multi-enzymatic biotransformation pathway of the novel cyano-cyclitol (1R,4S,5R,6R)/(1S,4R,5S
A short synthesis of (+)-cyclophellitol
Hansen, Flemming Gundorph,Bundgaard, Eva,Madsen, Robert
, p. 10139 - 10142 (2007/10/03)
A new synthesis of (+)-cyclophellitol, a potent β-glucosidase inhibitor, has been completed in nine steps from D-xylose. The key transformations involve a zinc-mediated fragmentation of benzyl-protected methyl 5-deoxy-5-iodo-xylofuranoside followed by a h
SYNTHETIC STUDIES ON ANTIBIOTIC VALIDAMYCINS. PART 12. TOTAL SYNTHESIS OF (+)-VALIDAMYCIN B AND (+)-VALIDOXYLAMINE B
Ogawa, Seiichiro,Miyamoto, Yasunobu,Nose, Taisuke
, p. 2675 - 2680 (2007/10/02)
The first complete synthesis of validamycin B (1a) and validoxylamine B (2a) is reported; coupling of the epoxide (12) and the partially protected derivative (16) of (+)-valienamine, followed by deprotection, gives (1a), which was identified from the 1H n
