119076-73-2Relevant academic research and scientific papers
Steroid-hindered 17β-tertiary alcohol: Characterization of dehydrated compounds
Bydal, Patrick,Sam, Kay-Mane,Poirier, Donald
, p. 349 - 353 (1996)
Five dehydrated compounds obtained from a tert- butyldimethylsilychloride/imidazole or an aqueous hydrochloric acid treatment of 17α-butyl-3-O-methyl estradiol in refluxing solvent were purified and characterized. Three compounds were obtained from a direct vicinal proton elimination, the two others from a vicinal elimination after migration of methyl-18. Depending on the treatment, the proportions of dehydrated compounds are different. In addition, a general profile of experimental conditions providing a similar mixture of dehydrated compounds was also established for this steroid-hindered 17β-tertiary alcohol.
