1190850-94-2Relevant academic research and scientific papers
Sugar-modified foldamers as conformationally defined and biologically distinct glycopeptide mimics
Siriwardena, Aloysius,Pulukuri, Kiran Kumar,Kandiyal, Pancham S.,Roy, Saumya,Bande, Omprakash,Ghosh, Subhash,Garcia Fernandez, Jose Manuel,Ariel Martin, Fernando,Ghigo, Jean-Marc,Beloin, Christophe,Ito, Keigo,Woods, Robert J.,Ampapathi, Ravi Sankar,Chakraborty, Tushar Kanti
, p. 10221 - 10226 (2013/10/21)
To fold or not to fold? It is shown that attached sugars play a defining role in the conformations adopted by a pair of novel SAA-derived foldamers in water and that these differences are reflected in the contrasting interactions of these glycofoldamers with various biological targets. C green, O red, N blue, H gray; yellow oval=mannose. Copyright
Synthesis and biological evaluation of novel gramicidin s analogues
Tuin, Adriaan Willem,Palachanis, Dimitrios Konstantinos,Buizert, Annelies,Grotenbreg, Gijsbert Marnix,Spalburg, Emile,De Neeling, Albert J.,Mars-Groenendijk, Roos H.,Noort, Daan,Van Der Marel, Gijsbert A.,Overkleeft, Herman S.,Overhand, Mark
experimental part, p. 4231 - 4241 (2011/02/24)
The synthesis of three new analogues of the cyclic cationic antimicrobial peptide Gramicidin S is described. These derivatives contain a modified turn region in which the DPhe-Pro motif has been replaced by a constrained furanoid sugar amino ac
