1190865-95-2Relevant academic research and scientific papers
Microwave-assisted synthesis of pyrazolo[3,4-b]pyridine- spirocycloalkanediones by three-component reaction of 5-aminopyrazole derivatives, paraformaldehyde and cyclic β-diketones
Quiroga, Jairo,Trilleras, Jorge,Pantoja, Dayana,Abonía, Rodrigo,Insuasty, Braulio,Nogueras, Manuel,Cobo, Justo
experimental part, p. 4717 - 4719 (2010/09/20)
New pyrazolo[3,4-b]pyridine-5-spirocycloalkanedione derivatives were prepared via three-component reaction between 5-(4-R-benzylamino)pyrazoles, cyclic β-diketones and paraformaldehyde. The use of indandione as β-diketone resulted in the formation of two products, the pyrazolo[3,4-b]pyridine-5-spiroindanediones and 3-tert-butyl-1-phenylindeno[2,3- e]pyrazolo[3,4-b]pyridine. The structures of the pyrazolo[3,4-b]pyridine-5- spirocycloalkanedione were confirmed by single-crystal X-ray diffraction. This protocol provides a simple one-step synthetic methodology with the advantages of easy work-up, mild reaction conditions and environmentally benign.
