1190882-89-3Relevant academic research and scientific papers
Highly efficient oxidation of amines to imines by singlet oxygen and its application in ugi-type reactions
Jiang, Gaoxl,Chen, Jian,Huang, Jie-Sheng,Che, Chi-Ming
, p. 4568 - 4571 (2009)
A variety of secondary benzylic amines were oxidized to imines in 90% to >99% yields by singlet oxygen generated from oxygen and a porphyrin photosensitizer. On the basis of these reactions, a protocol was developed for oxidative Ugi-type reactions with singlet oxygen as the oxidant. This protocol has been used to synthesize C1- and N-functionalized benzylic amines in up to 96% yields.
