119089-68-8

Basic information

• Product Name: 6H-Purin-6-one, 2-aMino-1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(phenylMethoxy)ethoxy]Methyl]-
• Synonyms: 6H-Purin-6-one, 2-aMino-1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(phenylMethoxy)ethoxy]Methyl]-;Mono benzyl ganciclovir;2-amino-9-({[1-(benzyloxy)-3-hydroxypropan-2-yl]oxy}methyl)-3,9-dihydro-6H-purin-6-one;2-amino-9-[(1-hydroxy-3-phenylmethoxypropan-2-yl)oxymethyl]-3H-purin-6-one
• CAS NO: 119089-68-8
• Molecular Formula: C₁₆H₁₉N₅O₄
• Molecular Weight: 345.35316
• Mol File: 119089-68-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 670.7°C at 760 mmHg
• Flash Point: 359.4°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 6.68E-19mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: 6H-Purin-6-one, 2-aMino-1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(phenylMethoxy)ethoxy]Methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 6H-Purin-6-one, 2-aMino-1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(phenylMethoxy)ethoxy]Methyl]-(119089-68-8)
• EPA Substance Registry System: 6H-Purin-6-one, 2-aMino-1,9-dihydro-9-[[1-(hydroxyMethyl)-2-(phenylMethoxy)ethoxy]Methyl]-(119089-68-8)

Safety Data

• Hazardous Substances Data: 119089-68-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H19N5O4/c17-16-19-14-13(15(23)20-16)18-9-21(14)10-25-12(6-22)8-24-7-11-4-2-1-3-5-11/h1-5,9,12,22H,6-8,10H2,(H3,17,19,20,23)

Upstream product

• 194204-55-2 2-(2-propionylamino-1,6-dihydro-6-oxo-purine-9-yl)methoxy-3-benzyloxy-1-propyl-propionate 
• 108436-61-9 2-(2-amino-1,6-dihydro-6-oxo-purine-9-yl)methoxy-3-benzyloxy-1-propyl-acetate 
• 194204-50-7 2-(2-amino-1,6-dihydro-6-oxo-purine-9-yl)methoxy-3-benzyloxy-1-propyl-propionate 

Relevant articles and documents

Process for preparing a 2-(2-amino-1, 6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative

wherein Z1is hydrogen or an amino-protecting group selected from the group consisting of acyl of the formula R—C(O)—, wherein R is alkyl of 1-6 carbon atoms; trityl, optionally substituted with methoxy; and N-(9-fluorenylmethoxycarbonyl); Y1is halo, aralkyloxy or acyloxy, wherein acyl is as defined above; and Y2is aralkyloxy. These intermediates are useful in a novel process for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol (ganciclovir). The mono-L-valine ester of ganciclovir and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.