1190924-31-2Relevant academic research and scientific papers
Azabenzthiazole inhibitors of leukotriene A4 hydrolase
Tanis, Virginia M.,Bacani, Genesis M.,Blevitt, Jonathan M.,Chrovian, Christa C.,Crawford, Shelby,De Leon, Aimee,Fourie, Anne M.,Gomez, Laurent,Grice, Cheryl A.,Herman, Krystal,Kearney, Aaron M.,Landry-Bayle, Adrienne M.,Lee-Dutra, Alice,Nelson, Jay,Riley, Jason P.,Santillán Jr., Alejandro,Wiener, John J.M.,Xue, Xiaohua,Young, Arlene L.
, p. 7504 - 7511 (2013/02/22)
Previously, benzthiazole containing LTA4H inhibitors were discovered that were potent (1-3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering c Log
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase
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Page/Page column 39, (2009/10/21)
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
