1190929-75-9Relevant academic research and scientific papers
Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers
Mahoney, Stuart J.,Lou, Tiantong,Bondarenko, Ganna,Fillion, Eric
supporting information; experimental part, p. 3474 - 3477 (2012/09/05)
Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).
Hydrogenolysis of unstrained carbon-carbon σ bonds: Stereoselective entry into benzylic tertiary centers
Wilsily, Ashraf,Nguyen, Yen,Fillion, Eric
supporting information; experimental part, p. 15606 - 15607 (2010/01/30)
(Chemical Equation Presented) The modification of sp3-hybridized carbon centers through Pd-catalyzed reductive cleavage of unstrained carbon-carbon @ bonds is described. From the hydrogenolysis of benzyl Meldrum's acids bearing an all-carbon be
