1190945-04-0

Basic information

• Product Name: 4-((5-(6-methoxynaphthalen-2-yl)-1-(3-methoxyphenyl)-3-oxopentyl)amino)benzoic acid
• CAS NO: 1190945-04-0
• Molecular Weight: 483.564
• Mol File: 1190945-04-0.mol

Chemical Properties

• CAS DataBase Reference: 4-((5-(6-methoxynaphthalen-2-yl)-1-(3-methoxyphenyl)-3-oxopentyl)amino)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((5-(6-methoxynaphthalen-2-yl)-1-(3-methoxyphenyl)-3-oxopentyl)amino)benzoic acid(1190945-04-0)
• EPA Substance Registry System: 4-((5-(6-methoxynaphthalen-2-yl)-1-(3-methoxyphenyl)-3-oxopentyl)amino)benzoic acid(1190945-04-0)

Safety Data

• Hazardous Substances Data: 1190945-04-0(Hazardous Substances Data)

Upstream product

• 42924-53-8 nabumetone 
• 64519-08-0 N-(3-Methoxybenzyliden)-4-aminobenzoesaeure 
• 150-13-0 4-amino-benzoic acid 
• 591-31-1 3-methoxy-benzaldehyde 

Relevant articles and documents

Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities

The synthesis of two series of β-amino ketones containing a p-aminobenzoic acid moiety (TM-1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by 1H NMR, 13C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The α-glucodase inhibition (α-GI) activity of compound 1e reached a remarkable level of 66.50%. The peroxisome proliferator-activated receptor (PPAR) relative activation activities of six compounds are above 80%, and in particular 2i displays an unprecedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also subject to further in-depth investigation.