1190948-58-3Relevant academic research and scientific papers
Convergent synthesis of diptoindonesin G
Singh, Dileep Kumar,Kim, Ikyon
, p. 300 - 301 (2019/01/04)
A convergent and scalable synthetic route to a tetracyclic oligostilbenoid natural product, diptoindonesin G, is described where Suzuki-Miyaura cross-coupling and intramolecular Friedel-Crafts acylation were employed to construct the central C ring of dip
Skeletal Reorganization: Synthesis of Diptoindonesin G from Pauciflorol F
Singh, Dileep Kumar,Kim, Ikyon
, p. 1667 - 1672 (2018/02/10)
Described herein is a novel synthetic approach to diptoindonesin G, a highly potent anticancer oligostilbenoid natural product, from pauciflorol F pentamethyl ether through a skeletal reorganization strategy where oxidative cleavage of the indanone ring system of pauciflorol F and sequential cyclization of the key intermediate allowed direct access to the target skeleton.
SYNTHESIS OF NOVEL ANALOGS OF DIPTOINDONESIN G, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Paragraph 0036; 0041, (2018/03/25)
Disclosed are unnatural analogs of Diptoindonesin G, methods to make the analogs, pharmaceutical compositions containing the analogs, and methods of using the analogs to inhibit neoplastic cell growth.
Total synthesis of diptoindonesin G and its analogues as selective modulators of estrogen receptors
Liu, Ji-Tian,Do, Truman J.,Simmons, Christopher J.,Lynch, John C.,Gu, Wen,Ma, Zhi-Xiong,Xu, Wei,Tang, Weiping
supporting information, p. 8927 - 8930 (2016/10/07)
We have developed a versatile synthetic strategy for the synthesis of the natural product diptoindonesin G and its analogues as selective modulators of estrogen receptors. The strategy involves a regioselective dehydrative cyclization of arylacetals, a regioselective bromination of benzofurans, a sequential cross-coupling of bromo-benzofurans with aryl boronic acids, and a BBr3-mediated tandem cyclization and demethylation. Preliminary biological studies uncovered the critical and dispensable phenolic hydroxyl groups in the natural product and also revealed unexpected selectivity for isoforms of estrogen receptor.
Total synthesis of diptoindonesin G via a highly efficient domino cyclodehydration/intramolecular friedel-crafts acylation/regioselective demethylation sequence
Kim, Kyungsun,Kim, Ikyon
supporting information; experimental part, p. 5314 - 5317 (2010/12/29)
A highly efficient total synthesis of diptoindonesin G is described employing a domino dehydrative cyclization/intramolecular Friedel-Crafts acylation/regioselective demethylation reaction of aryloxyketone 7 by the action of BCl3 wherein the tetracyclic 6H-anthra[1,9-bc]furan-6-one skeleton was constructed via the 3-arylbenzofuran in a one-pot manner. This is the first example of the strategic combination of these three reactions in a cascade fashion. The routes presented here allow for direct access to diptoindonesin G and its analogues.
