1190948-88-9Relevant academic research and scientific papers
Highly enantioselective Biginelli reaction catalyzed by SPINOL-phosphoric acids
Xu, Fangxi,Huang, Dan,Lin, Xufeng,Wang, Yanguang
, p. 4467 - 4470 (2012)
A highly enantioselective Biginelli reaction promoted by chiral spirocyclic SPINOL-phosphoric acids has been developed. Under the optimized conditions with 5 mol% catalyst loading, a wide range of optically active dihydropyrimidinethiones (DHPMs) were obtained in high yields (up to 98%) with good to excellent enantioselectivities (up to 99% ee). The synthetic utility of this method was demonstrated by the synthesis of chiral precursors of three drugs, including (S)-Monastrol, (S)-L-771688 and (S)-SQ 32926.
Highly enantioselective organocatalytic Biginelli and Biginelli-like condensations: Reversal of the stereochemistry by tuning the 3,3′-disubstituents of phosphoric acids
Li, Nan,Chen, Xiao-Hua,Song, Jin,Luo, Shi-Wei,Fan, Wu,Gong, Liu-Zhu
supporting information; experimental part, p. 15301 - 15310 (2010/01/30)
Organocatalytic enantioselective Biginelli and Biginelli-like reactions by chiral phosphoric acids derived from 3,3′-disubstituted binaphthols have been investigated. The size of 3,3′-substituents of the catalysts is able to control the stereochemistry of
