1190969-57-3Relevant academic research and scientific papers
Imidazo-pyrazine derivatives as potent CXCR3 antagonists
Du, Xiaohui,Gustin, Darin J.,Chen, Xiaoqi,Duquette, Jason,McGee, Lawrence R.,Wang, Zhulun,Ebsworth, Karen,Henne, Kirk,Lemon, Bryan,Ma, Ji,Miao, Shichang,Sabalan, Emmanuel,Sullivan, Timothy J.,Tonn, George,Collins, Tassie L.,Medina, Julio C.
, p. 5200 - 5204 (2009)
A general way of improving the potency of CXCR3 antagonists with fused hetero-bicyclic cores was identified. Optimization efforts led to the discovery of a series of imidazo-pyrazine derivatives with improved pharmacokinetic properties in addition to increased potency. The efficacy of the lead compound 21 is evaluated in a mouse lung inflammation model.
