1190984-57-6Relevant articles and documents
Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist
Satoh, Atsushi,Nagatomi, Yasushi,Hirata, Yukari,Ito, Satoru,Suzuki, Gentaroh,Kimura, Toshifumi,Maehara, Shunsuke,Hikichi, Hirohiko,Satow, Akio,Hata, Mikiko,Ohta, Hisashi,Kawamoto, Hiroshi
scheme or table, p. 5464 - 5468 (2010/06/19)
We identified 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide 27 as a potent mGluR1 antagonist. The compound possessed excellent subtype selectivity and good PK profile in rats. It also demonstrated relatively potent a