1190989-09-3

Basic information

• Product Name: (3,5-Difluoro-4-(Methoxycarbonyl)phenyl)boronic acid
• Synonyms: (3,5-Difluoro-4-(Methoxycarbonyl)phenyl)boronic acid
• CAS NO: 1190989-09-3
• Molecular Formula: C₈H₇BF₂O₄
• Molecular Weight: 215.9465864
• Mol File: 1190989-09-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 148-151 °C (decomp)
• Boiling Point: 370.1±52.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.56±0.11(Predicted)
• CAS DataBase Reference: (3,5-Difluoro-4-(Methoxycarbonyl)phenyl)boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-Difluoro-4-(Methoxycarbonyl)phenyl)boronic acid(1190989-09-3)
• EPA Substance Registry System: (3,5-Difluoro-4-(Methoxycarbonyl)phenyl)boronic acid(1190989-09-3)

Safety Data

• Hazardous Substances Data: 1190989-09-3(Hazardous Substances Data)

Usage

Uses

3,5-Difluoro-4-(methoxycarbonyl)phenylboronic acid

Upstream product

• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 1459732-44-5 methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzoate 
• 1459730-58-5 2,6-difluoro-4-(3-((7-fluoroquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzoic acid 
• 1459730-59-6 methyl 2,6-difluoro-4-(3-((7-fluoroquinolin-6-yl)methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)benzoate 
• 1350427-57-4 methyl 2,6-difluoro-4-(3-(quinolin-6-ylmethyl)-3H-[1,2,3]-triazolo[4,5-b]pyridin-5-yl)benzoate 

Relevant articles and documents

Functionalization of dihalophenylboronic acids by deprotonation of their N-butyldiethanolamine esters

Deprotonative lithiation of various 6-butyl-2-(dihalophenyl)-(N-B)-1,3,6,2- dioxazaborocanes (N-butyldiethanolamine esters of dihalophenylboronic acids) was investigated. It was found that selective transformations can be best achieved by use of LDA as the lithiating reagent. The reactivities of these compounds vary significantly, depending on the natures and positions of the halogen atoms. The resultant boron-lithium bimetallic intermediates were subjected to reactions with electrophiles to afford functionalized halogenated arylboronic acids.