1191-15-7

Basic information

• Product Name: Diisobutylaluminium hydride
• Synonyms: DiisobutylaluMinuM hydride, 1.5 M solution in toluene, J&KSeal;DiisobutylaluMinuM hydride, 1.0 M solution in hexanes, J&KSeal;DiisobutylaluMinuM hydride, 1.2 M solution in toluene, J&KSeal;DiisobutylaluMinuM hydride solution 1.0 M in cyclohexane;DiisobutylaluMinuM hydride solution 1.0 M in THF;DiisobutylaluMinuM hydride solution 1.0 M in toluene;DiisobutylaluMiniuM hydride, 1.0M solution in heptane, SpcSeal;DiisobutylaluMinuM hydride, 1.0 M solution in cyclohexane, SpcSeal
• CAS NO: 1191-15-7
• Molecular Formula: C₈H₁₉Al
• Molecular Weight: 142.22
• EINECS: 214-729-9
• Product Categories: Organometallics;Al (Alminum) Compounds;Biochemistry;Classes of Metal Compounds;Reagents for Oligosaccharide Synthesis;Reduction;Synthetic Organic Chemistry;Typical Metal Compounds;metal alkyl
• Mol File: 1191-15-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: -70 °C
• Boiling Point: 65 °C
• Flash Point: 40 °F
• Appearance: Clear/Solution
• Density: 1.23 g/mL at 25 °C
• Vapor Pressure: 13.3Pa at 90℃
• Storage Temp.: 2-8°C
• Solubility: Miscible with organic solvents.
• Water Solubility: vigorous reaction
• Sensitive: Air Sensitive/Heat Sensitive
• BRN: 4123663
• CAS DataBase Reference: Diisobutylaluminium hydride(CAS DataBase Reference)
• NIST Chemistry Reference: Diisobutylaluminium hydride(1191-15-7)
• EPA Substance Registry System: Diisobutylaluminium hydride(1191-15-7)

Safety Data

• Hazard Codes: F,T,C,N
• Statements: 14/15-17-35-40-67-65-63-48/20-11-34-19-62-51/53-23/24/25-20/21/22-15-14-50/53-37-22
• Safety Statements: 26-43-45-62-46-36/37/39-29-16-61-27-9
• RIDADR: UN 3399 4.3/PG 1
• WGK Germany: 2
• RTECS: BD0710000
• F: 1-4.3-10
• TSCA: Yes
• HazardClass: 4.3
• PackingGroup: I
• Hazardous Substances Data: 1191-15-7(Hazardous Substances Data)

Usage

Description

Diisobutylaluminium hydride (DIBALH, DIBAL, DIBAL-H or DIBAH) is a reducing agent with the formula (i-Bu2AlH)2, where i-Bu represents isobutyl (-CH2CH(CH3)2). It can be used for various homogeneous reductions such as alkynes to alkenes, esters or nitriles to aldehydes. It is available commercially as the neat reagent and as a solution in several different solvents (hexane, dichloromethane, tetrahydrofuran, etc.). The neat reagent is a liquid and is supplied in metal cylinders. It is pyrophoric and highly reactive and therefore must be handled with great care. The molar solutions in organic solvents are more stable and easier to handle provided that the normal precautions are taken for working with air-sensitive compounds. They must all be handled in an atmosphere free from oxygen and water. Commonly used solvents for diisobutylaluminium hydride are dichloromethane, diglyme, dioxane and tetrahydrofuran. Even when the substrate is not completely soluble in these solvents successful reductions can be accomplished.

Chemical Properties

Diisobutylaluminium hydride, also known as Dibal. colorless liquid. Viscosity 18.0mPa-s(25℃). Reacts violently with water to form hydrogen and isobutane. Tetrahydrofuran is not suitable as Dibal solvent, because the two react to produce coordination compounds. Diisobutylaluminium hydride is a useful reducing agent in organic synthesis. It can reduce ketones, carboxylic acids and esters to the corresponding alcohols. Dibal can also reduce lactones to o-hydroxy lactones.

Uses

Different sources of media describe the Uses of 1191-15-7 differently. You can refer to the following data:
1. Diisobutylaluminum hydride is commonly used as a reducing agent in organic synthesis.Diisobutylaluminum hydride can be used in the following protocols:As a promotor of Tishchenko reaction of aldehydes.Conversion of benzylidene acetals of 1,2-and 1,3-glycols to the corresponding monobenzyl ethers of the glycols.To generate a novel chiral reducing agent based on (S)-proline for the asymmetric reduction of prochiral ketones.
2. Diisobutylaluminum hydride is used as reducing agent in pharmaceuticals. It is also used as raw material in organic synthesis, agrochemicals and dyestuffs.
3. Diisobutylaluminum hydride (DIBAL-H) is a common reducing agent to reduce aldehydes, ketones, esters, acids and acid chlorides to the corresponding alcohols. Some of the applications are:Synthesis of α-acetoxy ethers by reduction and subsequent acetylation of esters.Synthesis of coniferyl, sinapyl, and p-coumaryl alcohol by selective reduction of corresponding cinnamate esters.Reduction of secondary phosphine oxides (SPOs) to the corresponding phosphines.DIBAL-H can also be used in the hydroalumination of alkene and alkynes.

Flammability and Explosibility

Spontaneouslyflammableinair(pyrophoric)

Safety Profile

Mddly toxic by inhalation. Dangerous fire hazard; iptes spontaneously in air. To fight fire, do not use water, foam, or halogenated extinguisking agents. See also HYDRIDES and ALUMINUM COMPOUNDS.

InChI:InChI=1/2C4H9.Al.H/c2*1-4(2)3;;/h2*4H,1H2,2-3H3;;/q;;+1;-1/rC8H18Al.H/c1-7(2)5-9-6-8(3)4;/h7-8H,5-6H2,1-4H3;/q+1;-1

Synthetic route

triisobutylaluminum (100-99-2) → diisobutylaluminium hydride (1191-15-7)

diethyl ether (60-29-7) + water (7732-18-5) → diisobutylaluminium hydride (1191-15-7)

Conditions	Yield
With hydrogenchloride; diisobutylaluminium hydride In tetrahydrofuran; methanol
With hydrogenchloride; diisobutylaluminium hydride In tetrahydrofuran; methanol
With hydrogenchloride; diisobutylaluminium hydride In tetrahydrofuran; methanol

triisobutylaluminum (100-99-2) → diisobutyl aluminium (1+); isobutylate (5587-58-6) + diisobutylaluminium hydride (1191-15-7)

Conditions	Yield
With water bubbling moistened helium stream (O2<0.001%) through Al-compd. (Drechsel vessel, room temp.); gas-liquid chromatographic anal., mass spectroscopy;

[rac-1,2-ethylene-bis(η5-4,5,6,7-tetrahydroindenyl)]dichloridezirconium(IV) + diisobutylaluminum chloride (1779-25-5) → rac-C2H4(4,5,6,7-tetrahydroindenyl)2ZrCl(μ-H)2Al(i-Bu)2 + rac-C2H4(4,5,6,7-tetrahydroindenyl)2ZrH(μ-H)2Al(i-Bu)2 + diisobutylaluminium hydride (1191-15-7)

Conditions	Yield
In (2)H8-toluene toluene-d7, 1 equiv of Al-compound, 25°C; not sepd., detected by NMR spectra;

2-chlorophenylacetylene (873-31-4) + diisobutylaluminium hydride (1191-15-7) → ClC6H4CHCHAl(CH2CH(CH3)2)2 + ClC6H4CCAl(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= >98:2;	A n/a B 2% C n/a

1-ethynyl-3-methoxybenzene + diisobutylaluminium hydride (1191-15-7) → CH3OC6H4CHCHAl(CH2CH(CH3)2)2 + CH3OC6H4CCAl(CH2CH(CH3)2)2 + CH3OC6H4CCH2Al(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β=>98:2;	A n/a B 2% C n/a

3-ethynylthiophene (67237-53-0) + diisobutylaluminium hydride (1191-15-7) → C4H3SCHCHAl(CH2CH(CH3)2)2 + C4H3SCCAl(CH2CH(CH3)2)2 + C4H3SCCH2Al(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= >98:2;	A n/a B 2% C n/a

1-ethynyl-3-trifluoromethylbenzene (705-28-2) + diisobutylaluminium hydride (1191-15-7) → CF3C6H4CHCHAl(CH2CH(CH3)2)2 + CF3C6H4CCH2Al(CH2CH(CH3)2)2 + CF3C6H4CCAl(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 4°C, 12 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= 95:5;	A n/a B n/a C 2%

3-Ethynylpyridine (2510-23-8) + diisobutylaluminium hydride (1191-15-7) → C5H4NCHCHAl(CH2CH(CH3)2)2 + C5H4NCCAl(CH2CH(CH3)2)2 + C5H4NCCH2Al(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= >98:2;	A n/a B 2% C n/a

1-ethynyl-2-methoxybenzene (767-91-9) + diisobutylaluminium hydride (1191-15-7) → CH3OC6H4CHCHAl(CH2CH(CH3)2)2 + CH3OC6H4CCAl(CH2CH(CH3)2)2 + CH3OC6H4CCH2Al(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 4°C, 12 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β=98:2;	A n/a B 2% C n/a

diisobutylaluminium hydride (1191-15-7) + 4-methoxyphenylacetylen (768-60-5) → CH3OC6H4CHCHAl(CH2CH(CH3)2)2 + CH3OC6H4CCAl(CH2CH(CH3)2)2 + CH3OC6H4CCH2Al(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 4°C, 12 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β=>98:2;	A n/a B 2% C n/a

4-trifluoromethylphenylacetylene (705-31-7) + diisobutylaluminium hydride (1191-15-7) → CF3C6H4CHCHAl(CH2CH(CH3)2)2 + CF3C6H4CCH2Al(CH2CH(CH3)2)2 + CF3C6H4CCAl(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= 97:3;	A n/a B n/a C 2%

2-bromo-1-ethynylbenzene (766-46-1) + diisobutylaluminium hydride (1191-15-7) → BrC6H4CHCHAl(CH2CH(CH3)2)2 + BrC6H4CCAl(CH2CH(CH3)2)2 + BrC6H4CCH2Al(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= >98:2;	A n/a B 2% C n/a

diisobutylaluminium hydride (1191-15-7)

Conditions	Yield
bis(diphenylphosphino)butane nickel(II) dichloride In tetrahydrofuran byproducts: C6H5CHCHC(CH2)C6H5; 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min);	A n/a B n/a C 2%
nickel(II) chloride hexahydrate In tetrahydrofuran byproducts: C6H5CHCHC(CH2)C6H5; 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min);	A n/a B n/a C 2%
nickel(II) acetylacetonate In tetrahydrofuran byproducts: C6H5CHCHC(CH2)C6H5; 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min);	A n/a B n/a C 2%

1-ethynyl-4-fluorobenzene + diisobutylaluminium hydride (1191-15-7) → FC6H4CHCHAl(CH2CH(CH3)2)2 + FC6H4CCAl(CH2CH(CH3)2)2 + FC6H4CCH2Al(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 22°C, 2 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= >98:2;	A n/a B 2% C n/a

1-ethynyl-2-methylbenzene (766-47-2) + diisobutylaluminium hydride (1191-15-7) → CH3C6H4CHCHAl(CH2CH(CH3)2)2 + CH3C6H4CCH2Al(CH2CH(CH3)2)2 + CH3C6H4CCAl(CH2CH(CH3)2)2

Conditions	Yield
1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran 3 mol% of Ni-catalyst, 1.3 equiv of Al-compound, THF, 4°C, 12 h, N2 atm.; detected by NMR spectra after quench with D2O (0°C, 30 min); α:β= >98:2;	A n/a B n/a C 2%

N-(2,6-diisopropylphenyl)-N-((1E)-1-(6-[(1E)-N-(2,6-diisopropylphenyl)ethanimidoyl]pyridin-2-yl)ethylidene)amine (204203-14-5) + diisobutylaluminium hydride (1191-15-7) → [Al(CH2CH(CH3)2)2(C5H4N(CCH3NC6H3(CH(CH3)2)2)2)] (879935-67-8) + (Al(CH2CH(CH3)2)2(C5H4N(CCH3NC6H3(CH(CH3)2)2)2))2

Conditions	Yield
In hexane under Ar; AlH(i-Bu)2 added to soln. of ligand in hexane, cooling, crystals of mono-Al complex isolated, soln. heated at 110°C for 2 h; cooling overnight yields crystals of di-Al complex; elem. anal.;	A n/a B 10.7%

diisobutylaluminium hydride (1191-15-7) + 2-cyano-6-styrylpyridine (87884-41-1) → trans-C-(6-Styryl-pyridin-2-yl)-methylamine hydrochloride

Conditions	Yield
In tetrahydrofuran; toluene	17%

oct-1-ene (111-66-0) + diisobutylaluminium hydride (1191-15-7) → octylidenebis(diisobutylaluminium) (4145-75-9)

Conditions	Yield
zirconocene dichloride In benzene Kinetics; (Ar); mixture of Zr complex, olefine and soln. of organoaluminum compd. diluted with benzene, stirred at 20 °C for 5 h;	17%
With hydrogenchloride; meso-Me2C(2-Me-4-But-C5H2)2ZrCl2 In water; benzene at 0 - 20℃; Reagent/catalyst; Inert atmosphere;

1-hexene (592-41-6) + diisobutylaluminium hydride (1191-15-7) → (i-Bu)2AlC6H13 (75925-84-7)

Conditions	Yield
zirconocene dichloride In benzene (Ar); mixture of Zr complex, olefine and soln. of organoaluminum compd. diluted with benzene, stirred at 20 °C for 5 h;	17%

C24H28O9 + diisobutylaluminium hydride (1191-15-7) → C27H34O9

Conditions	Yield
Stage #1: diisobutylaluminium hydride With isopropyl alcohol In toluene at 25℃; Stage #2: C24H28O9 In toluene at 25 - 60℃; Sealed tube;	17%

1-Heptene (592-76-7) + diisobutylaluminium hydride (1191-15-7) → (i-Bu)2AlC7H15 (54542-96-0)

Conditions	Yield
zirconocene dichloride In benzene (Ar); mixture of Zr complex, olefine and soln. of organoaluminum compd. diluted with benzene, stirred at 20 °C for 5 h;	18%

1-Decene (872-05-9) + diisobutylaluminium hydride (1191-15-7) → (i-Bu)2AlC10H21 (888318-69-2)

Conditions	Yield
zirconocene dichloride In benzene (Ar); mixture of Zr complex, olefine and soln. of organoaluminum compd. diluted with benzene, stirred at 20 °C for 5 h;	18%

piperidin-1-yl benzoate (5542-49-4) + diisobutylaluminium hydride (1191-15-7) + phenylacetylene (536-74-3) → 1-(1-phenylvinyl)piperidine (14990-66-0)

Conditions	Yield
Stage #1: diisobutylaluminium hydride; phenylacetylene With bis(triphenylphosphine)nickel(II) chloride In tetrahydrofuran at 22℃; for 3h; Inert atmosphere; Stage #2: piperidin-1-yl benzoate With copper(l) chloride In tetrahydrofuran at 22℃; for 1h; Inert atmosphere;	18%

non-1-ene (124-11-8) + diisobutylaluminium hydride (1191-15-7) → (i-Bu)2AlC9H19 (893418-22-9)

Conditions	Yield
zirconocene dichloride In benzene (Ar); mixture of Zr complex, olefine and soln. of organoaluminum compd. diluted with benzene, stirred at 20 °C for 5 h;	19%
With hydrogenchloride; meso-Me2C(2-Me-4-But-C5H2)2ZrCl2 In water; benzene at 0 - 20℃; Reagent/catalyst; Inert atmosphere;

2-naphthyl triflate (3857-83-8) + diisobutylaluminium hydride (1191-15-7) → 2,2'-binaphthalene (612-78-2) + 2-iso-butylnaphthalene (26490-07-3)

Conditions	Yield
With diisobutylaluminium hydride; trans-bis(triphenylphosphine)palladium dichloride In tetrahydrofuran Ambient temperature;	A 10% B 20%
trans-bis(triphenylphosphine)palladium dichloride In tetrahydrofuran Ambient temperature;	A 10% B 20%

potassium (7440-09-7) + diisobutylaluminium hydride (1191-15-7) → dipotassium tetraisobutyldihydridodialuminate

Conditions	Yield
In hexane byproducts: KAl(i-Bu)3H, KAl(i-Bu)2H2, Al; mixed at -30°C, stirred (36 h, 20°C); filtered (Ar), residue washed (abs. ether), filtrate distilled off, hexane was added; elem. anal.;	20%

methylallylether (627-40-7) + diisobutylaluminium hydride (1191-15-7) → (3-methoxypropyl)diisobutylaluminum

Conditions	Yield
In hexane under N2 atm. to allyl methyl ether was added dropwise soln. i-Bu2AlH inn-hexane at room temp., react. mixt. was heated to 45°C, soln. i -Bu2AlH was added and refluxed for 4 h; solvent was removed in vacuo, residue was distilled fractionally; elem. anal.;	20%

1-(2',4',6'-tri-tert-butylphenyl)acetylene (31039-85-7) + diisobutylaluminium hydride (1191-15-7) → C56H94Al2

Conditions	Yield
In pentane at 20℃; for 12h; Inert atmosphere;	20%

{(C6H2-2,6-(C6H3-2,4,6-Me3)2)Sn(μ-Cl)}2 + diisobutylaluminium hydride (1191-15-7) → C96H104Sn4

Conditions	Yield
In diethyl ether; hexane at -78℃; for 2h; Schlenk technique;	21%

Cp*2TiF2 (87050-22-4) + diisobutylaluminium hydride (1191-15-7) → Cp*2Ti(μ-H)2AliBu2

Conditions	Yield
In tetrahydrofuran; cyclohexane at 20℃; Inert atmosphere; Schlenk technique; Glovebox;	23%

Upstream product

• 1779-25-5 diisobutylaluminum chloride 
• 100-99-2 triisobutylaluminum 
• 60-29-7 diethyl ether 
• 7732-18-5 water 

Downstream Products

• 777940-25-7 {4-[6-Methyl-2-(2,4,6-trimethylphenylamino)-pyridine-3-sulfonyl]-phenyl}-methanol 
• 321748-87-2 (2RS)-(3RS)-3-(2-benzyl-3-dimethylamino-1-ethylpropyl)-phenol hydrochloride 
• 267875-59-2 5-Hydroxymethyl-6-methylbenzimidazole 
• 82072-23-9 3-(bromomethyl)benzaldehyde 
• 126222-99-9 (4S,5R)-4-(cyclohexylmethyl)-2-oxo-5-oxazolidinecarboxaldehyde 
• 189011-92-5 3-[2-(4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)ethylamino]-N-[2-(2-phenyl-propoxy)ethyl]propanesulphonamide hydrochloride 
• 189011-95-8 3-[2-(4-Hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)ethylamino]-N-[2-(2-phenylthioethoxy)ethyl]propanesulphonamide hydrochloride 
• 7517-02-4 isopropoxydiisobutylaluminum 
• 1590-87-0 disilane 
• 15769-72-9 diisobutyl-aluminum-ethylate 
• 76229-55-5 diisobutyl-(2,6-di-tert-butylphenoxy) aluminium 
• 174676-33-6 (2-bromomethyl-cyclohex-1-enyl)-trimethyl-stannane 

Relevant articles and documents

Alkylaluminum-complexed zirconocene hydrides: Identification of hydride-bridged species by NMR spectroscopy

Reactions of unbridged zirconocene dichlorides, (RnC 5H5-n)2ZrCl2 (n=0, 1, or 2), with diisobutylaluminum hydride (HAI'Bu2) result in the formation of tetranuclear trihydride clusters of the type (RnC5H 5-n)2Zr(μ-H)3(Al iBu2)3(μ-CI) 2, which contain three [Al iBu2] units. Ring-bridged ansa-zirconocene dichlorides, Me2E(RnC5H 4-n)2ZrCl2 with E=C or Si, on the other hand, are found to form binuclear dihydride complexes of the type Me2E(R nC5H4-n)2Zr(CI)(μ-H) 2Al iBu2 with only one [AIBu2] unit. The dichotomy between unbridged and bridged zirconocene derivatives with regard to tetranuclear versus binuclear product formation is proposed to be connected to different degrees of rotational freedom of their C5-ring ligands. Alkylaluminum-complexed zirconocene dihydrides, previously observed in zirconocene-based precatalyst systems activated by methylalumoxane (MAO) upon addition of HAI'Bu2 or Al iBu3, are proposed to be species of the type Me2Si(ind)2Zr(Me)(μ-H) 2Al iBu2, stabilized by interaction of their terminal Me group with a Lewis acidic site of MAO.

Pyronin antibacterials, process and novel intermediates thereto

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

Aminediol protease inhibitors

Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).