1191-39-5

Usage

Uses

Used in Polymeric Materials Production:
N-Dodecylmethacrylamide is used as a monomer in the production of polymeric materials such as hydrogels, adhesives, and coatings. Its incorporation enhances the properties of these materials, providing them with improved stability and performance.
Used in Drug Delivery Systems:
In the pharmaceutical industry, N-Dodecylmethacrylamide is used as a component in the synthesis of polymers for drug delivery systems. Its unique properties allow for the development of controlled release formulations, which can improve the efficacy and safety of drug administration.
Used in Tissue Engineering:
N-Dodecylmethacrylamide is also utilized in the field of tissue engineering, where it contributes to the creation of biocompatible materials that can support cell growth and tissue regeneration.
Used as a Surfactant:
In various industries, including household products, N-Dodecylmethacrylamide is used as a surfactant. Its surfactant properties enable it to reduce the surface tension of liquids, facilitating processes such as emulsification, dispersion, and cleaning.

InChI:InChI=1/C16H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-17-16(18)15(2)3/h2,4-14H2,1,3H3,(H,17,18)

Upstream product

• 124-22-1 n-Dodecylamine 
• 920-46-7 Methacryloyl chloride 

Relevant academic research and scientific papers

METHOD OF PRODUCING N-SUBSTITUTED (METH)ACRYLAMIDE

PROBLEM TO BE SOLVED: To provide a method of producing N-substituted (meth)acrylamide of high purity under mild conditions. SOLUTION: This invention relates to a method of obtaining N-substituted (meth)acrylamide [3] by the detachment of an amine compound through the liquid-phase thermal decomposition of an aminopropionic acid amide derivative [1] in the presence of a catalyst mainly composed of silica, wherein R1-R5 are represented by H, a C1-32 alkyl group, and a hydroxyalkyl group. COPYRIGHT: (C)2016,JPOandINPIT

A fluorescent polymeric heparin sensor

Linear copolymers have been developed which carry binding sites tailored for sulfated sugars. All binding monomers are based on the methacrylamide skeleton and ensure statistical radical copolymerization. They are decorated with o-aminomethylphenylboronates for covalent ester formation and/ or alkylammonium ions for noncovalent Coulomb attraction. Alcohol sidechains maintain a high water solubility; a dansyl monomer was constructed as a fluorescence label. Statistical copoly merization of comonomer mixtures with optimized ratios was started by AIBN (AIBN = 2,2′-azoisobutyronitrile) and furnished water-soluble comonomers with an exceptionally high affinity for glucosaminoglucans. Heparin can be quantitatively detected with an unprecedented 30 nM sensitivity, and a neutral polymer without any ammonium cation is still able to bind the target with almost micromolar affinity. From this unexpected result, we propose a new binding scheme between the boronate and a sulfated ethylene glycol or aminoethanol unit. Although the mechanism of heparin binding involves covalent boronate ester formation, it can be completely reversed by protamine addition, similar to heparin's complex formation with antithrombin III.

Tuning linear copolymers into protein-specific hosts

Being picky: A new concept for selective protein recognition by artificial receptor molecules involves statistical copolymerization of simple binding monomers in defined stoichiometric ratios. As an example of its efficiency, an arginine-rich lysozyme is recognized by a bisphosphonate-rich copolymer with a remarkable Kd value of 25 nM, 100-times superior to that of cytochrome c, which is comparable in size and isoelectric point. (Chemical Equation Presented).