119105-31-6Relevant articles and documents
Copper-catalyzed asymmetric allylic alkylation of racemic cyclic substrates: Application of dynamic kinetic asymmetric transformation (DYKAT)
Langlois, Jean-Baptiste,Alexakis, Alexandre
supporting information; experimental part, p. 447 - 457 (2010/06/13)
The copper-catalyzed asymmetric allylic alkylation (AAA) is of great interest in organic synthesis. This reaction was extensively studied using a broad range of substrates, ligands and organometallic reagents. However, the use of racemic substrates was still limited. Although some processes of kinetic resolution are reported in the literature, no examples of quantitative deracemization are described as is the case for the Pd-catalyzed allylic alkylation. We present here a full account of our investigations through the development of the first example of such a process in copper-catalyzed AAA. High enantioselectivities (up to 99% ee), scope of the reaction and mechanistic considerations are reported herein.
Stereo controlled synthesis of 1β-aminoalkylcarbapenems and tricyclic carbapenems (trinems)
Iso, Yasuyoshi,Nishitani, Yasuhiro
, p. 2287 - 2308 (2007/10/03)
The effective synthesis of 1β-aminoalkylcarbapenems and trinems are described and the antibacterial activities of new carbapenem derivatives prepared by this advantageous synthetic method are also reported.
