1191105-49-3Relevant academic research and scientific papers
An efficient synthesis of isoquinolines via rhodium-catalyzed direct C-H functionalization of arylhydrazines
Zhang, Sai,Huang, Daorui,Xu, Guangyang,Cao, Shengyu,Wang, Rong,Peng, Shiyong,Sun, Jiangtao
, p. 7920 - 7923 (2015)
A highly efficient rhodium-catalyzed C-H activation of arylhydrazines and coupling with internal alkynes has been realized under mild conditions. The isoquinolines have been prepared in moderate to excellent yields in high efficiency. This methodology features the use of readily available starting materials, and a simple hydrazine moiety as a directing group, in the absence of an external metal co-oxidant under an air atmosphere. The C-H bond activation and the N-N bond cleavage have been successively realized under mild conditions.
Cobalt-catalyzed redox-neutral synthesis of isoquinolines: C–H activation assisted by an oxidizing N–S bond
Wang, Fen,Wang, Qiang,Bao, Ming,Li, Xingwei
, p. 1423 - 1430 (2016/09/07)
A redox-neutral avenue to access isoquinolines has been realized by a Co(III)-catalyzed C–H activation process. Starting from readily available N-sulfinyl imine substrates and alkynes, the reaction occurred via N–S cleavage with broad substrate scope and functional group compatibility in the presence of cost-effective cobalt catalysts.
Realized C-H functionalization of aryldiazo compounds via rhodium relay catalysis
Qiu, Lin,Huang, Daorui,Xu, Guangyang,Dai, Zhenya,Sun, Jiangtao
supporting information, p. 1810 - 1813 (2015/04/14)
An unprecedented C-H functionalization of aryldiazo compounds without a preinstallation of directing group has been realized under mild conditions, which differs from former reports in its use of diazo compounds as coupling partners in directed C-H activations. This novel transformation has been realized by a rhodium self-relay catalysis, a tandem process of the in situ formation of a directing group and sequential C-H bond activation.
Rhodium-catalyzed oxidative coupling of aryl hydrazones with internal alkynes: Efficient synthesis of multisubstituted isoquinolines
Liu, Wenting,Hong, Xiaohu,Xu, Bin
, p. 2137 - 2149 (2013/08/23)
An efficient rhodium-catalyzed oxidative coupling reaction has been developed that gives high yields of multisubstituted isoquinolines from easily accessible aryl hydrazones and internal alkynes. Indenone hydrazone can also be synthesized in high yield from the corresponding benzaldehyde hydrazone by using this approach.
Rhodium-catalyzed oxidative coupling of aromatic imines with internal alkynes via regioselective C-H bond cleavage
Fukutani, Tatsuya,Umeda, Nobuyoshi,Hirano, Koji,Satoh, Tetsuya,Miura, Masahiro
supporting information; experimental part, p. 5141 - 5143 (2009/12/08)
The rhodium-catalyzed oxidative coupling of aromatic imines with alkynes effectively proceeds via regioselective C-H bond cleavage to produce indenone imine and isoquinoline derivatives. The Royal Society of Chemistry 2009.
