1191105-51-7Relevant articles and documents
Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids
Hu, Kun,Qi, Linjun,Yu, Shuling,Cheng, Tianxing,Wang, Xiaodong,Li, Zhaojun,Xia, Yuanzhi,Chen, Jiuxi,Wu, Huayue
, p. 1740 - 1750 (2017/06/07)
A palladium-catalyzed tandem reaction of 2-(cyanomethyl)benzonitriles or 2-(2-carbonylphenyl)acetonitriles with arylboronic acids in water has been developed for the first time. This reaction features good functional group tolerance and provides a new strategy for the synthesis of diverse isoquinolines under mild conditions. The use of water as the reaction medium makes the synthesis process environmentally benign. Preliminary mechanistic experiments indicate that the major reaction pathway involves carbopalladation of the C(sp3)-cyano group and subsequent intramolecular cyclization findings that were further supported by density functional theory (DFT) calculations.
(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Oxidative [4+2] Annulation of N H Imines with Alkynes: Straightforward Synthesis of Multisubstituted Isoquinolines
Zhang, Shang-Shi,Liu, Xu-Ge,Chen, Shi-Yong,Tan, Dong-Hang,Jiang, Chun-Yong,Wu, Jia-Qiang,Li, Qingjiang,Wang, Honggen
supporting information, p. 1705 - 1710 (2016/10/13)
A synthetic method for isoquinoline synthesis via a [4+2] annulation of N H imines with alkynes using the high-valent (pentamethylcyclopentadienyl)cobalt(III) [Cp*Co(III)] catalyst is described. Cerium(IV) sulfate was found to be an efficient oxidant in lieu of the commonly used copper or silver salts. Broad substrate scope, high functional group tolerance, and generally good yields were observed. (Figure presented.).
An efficient synthesis of isoquinolines via rhodium-catalyzed direct C-H functionalization of arylhydrazines
Zhang, Sai,Huang, Daorui,Xu, Guangyang,Cao, Shengyu,Wang, Rong,Peng, Shiyong,Sun, Jiangtao
supporting information, p. 7920 - 7923 (2015/07/27)
A highly efficient rhodium-catalyzed C-H activation of arylhydrazines and coupling with internal alkynes has been realized under mild conditions. The isoquinolines have been prepared in moderate to excellent yields in high efficiency. This methodology features the use of readily available starting materials, and a simple hydrazine moiety as a directing group, in the absence of an external metal co-oxidant under an air atmosphere. The C-H bond activation and the N-N bond cleavage have been successively realized under mild conditions.
