119111-65-8

Basic information

• Product Name: 1-(Dimethylamino)cyclopropanecarboxylicacid
• Synonyms: 1-(Dimethylamino)cyclopropanecarboxylicacid;1-(N,N-dimethylamino)cyclopropanecarboxylic acid;1-(Dimethylamino)
• CAS NO: 119111-65-8
• Molecular Formula: C₆H₁₁NO₂
• Molecular Weight: 129.15704
• Mol File: 119111-65-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 221 °C at 760 mmHg
• Flash Point: 87.5 °C
• Appearance: /
• Density: 1.16 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(Dimethylamino)cyclopropanecarboxylicacid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Dimethylamino)cyclopropanecarboxylicacid(119111-65-8)
• EPA Substance Registry System: 1-(Dimethylamino)cyclopropanecarboxylicacid(119111-65-8)

Safety Data

• Hazardous Substances Data: 119111-65-8(Hazardous Substances Data)

Usage

General Description

1-(Dimethylamino)cyclopropanecarboxylic acid is a chemical compound with the molecular formula C7H13NO2. It is a cyclopropane-derived carboxylic acid containing a dimethylamino group and is used as a building block in organic synthesis. 1-(Dimethylamino)cyclopropanecarboxylicacid is a colorless liquid with a faint odor, and it is soluble in water and organic solvents. It has been used in the pharmaceutical industry as a potential precursor for the synthesis of biologically active compounds. Additionally, it has been studied for its potential use in the development of new drugs and other applications in the field of medicinal chemistry.

Upstream product

• 50-00-0 formaldehyd 
• 22059-21-8 aminocyclopropane-1-carboxylic acid 

Downstream Products

• 1235841-71-0 N-(2-(4-(4-cyano-1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)-phenoxy)ethyl)-1-(dimethylamino)-N-methylcyclopropanecarboxamide 
• 959840-95-0 C₂₄H₃₀FN₅O₃ 

Relevant articles and documents

N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES

The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein X, a, b, C, D, L2,L3, Y1, Y2, R2, R4, R5, R6, z2, z4, z5, and z6 are as defined herein, and salts thereof. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to compounds for use in methods of inhibiting the ATF4 (activating transcription factor 4) pathway and treatment of disorders associated therewith, such as e.g. cancer, neurodegenerative diseases and many other diseases, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. Preferred compounds of the invention are N-(3-(2-(4-chlorophenoxy) acetamido)bicyclo[1.1.1]pentan-l-yl)-2-cyclobutane-l-carboxamide derivatives and related compounds.

DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS

Compound formula I: wherein: X1 and X2 may be either (a) C and O, (b) N and N, or (c) C and NH, where the dotted bonds represents a double bond in the appropriate location; R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; RN1 is selected from hydrogen and an optionally substituted C1-4 alkyl group; RC1 is selected from an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group; or RN1 and RC1 may together form an optionally substituted C2-4 alkylene group.