119119-23-2

Upstream product

• 119119-21-0 (5E,7Z)-1-(4-Methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-9-(tetrahydro-pyran-2-yloxy)-nona-5,7-dien-4-ol 
• 119119-13-0 (E)-3-[(1S,2R,3R,4R)-3-(Tetrahydro-pyran-2-yloxymethyl)-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl]-acrylic acid ethyl ester 
• 119119-15-2 (E)-3-[(1S,2R,3R,4R)-3-(Tetrahydro-pyran-2-yloxymethyl)-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl]-propenal 
• 119119-22-1 (6E,8Z)-5-Hydroxy-10-(tetrahydro-pyran-2-yloxy)-deca-6,8-dienoic acid methyl ester 
• 119119-14-1 (E)-3-[(1S,2R,3R,4R)-3-(Tetrahydro-pyran-2-yloxymethyl)-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl]-prop-2-en-1-ol 
• 119119-12-9 (E)-3-((1R,2S,3S,4S)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl)-acrylic acid ethyl ester 
• 119119-20-9 (2E,4Z)-6-(Tetrahydro-pyran-2-yloxy)-hexa-2,4-dienal 

Downstream Products

• 70968-99-9 (=/-)-5-hydroxy-6-trans-8,11,14,-cis-eicosatetraenoic acid methyl ester 
• 71030-39-2 (+/-)-5-HETE 
• 89682-46-2 (6E,8Z)-5-(tert-Butyl-diphenyl-silanyloxy)-icosa-6,8-diene-11,14-diynoic acid methyl ester 
• 89682-45-1 (6E,8Z)-10-Bromo-5-(tert-butyl-diphenyl-silanyloxy)-deca-6,8-dienoic acid methyl ester 

Relevant academic research and scientific papers

A New Stereoselective Synthesis of (E,Z)-Conjugated Hydroxy-Dienes, Key Intermediates for the Synthesis of HETES

A general and highly stereoselective synthesis of (E,Z)-conjugated hydroxy-dienes is described and its synthetic utility is illustrated by the synthesis of precursors of (+/-)-LTA4 methyl ester and (+/-)-5-HETE respectively.