1191238-76-2Relevant academic research and scientific papers
[1,2]-Anionic rearrangement of 2-benzyloxypyridine and related pyridyl ethers
Yang, Jingyue,Dudley, Gregory B.
supporting information; experimental part, p. 7998 - 8000 (2010/03/01)
(Chemical Equation Presented) An anionic rearrangement of 2-benzyloxypyridine is described. Pyridine-directed metalation of the benzylic carbon leads to 1,2-migration of pyridine via a postulated associative mechanism (addition/elimination). Several aryl pyridyl carbinols were obtained in high yields. A formal synthesis of carbinoxamine, an antihistamine drug used for the treatment of seasonal allergies and hay fever, emerges from this methodology.
