119124-15-1Relevant academic research and scientific papers
Diastereoselective reduction of E and Z α-alkoxyimino-β-ketoesters by sodium borohydride
Correa Jr., Ivan R.,Moran, Paulo J. S.
, p. 14221 - 14232 (2007/10/03)
The reduction of (Z)-α-alkoxyimino-β-ketoesters, R1COC(= NOR3)CO2R2 (R1 = Me, Et, MeOCH2, Ph; R2 = Me, Et, PhCH2; R3 = Me, PhCH2) with NaBH4
Synthesis and biological activity of new C-6 and C-7 substituted vinyloxyimino-penicillins and -cephalosporins
Fell, Stephen C. M.,Pearson, Michael J.,Burton, George,Elder, John S.
, p. 1483 - 1494 (2007/10/02)
The Wittig reaction has been successfully utilized in the preparation of a number of substituted α-vinyloxyiminoacetic acids, the subsequent coupling of which to the 6-APA and 7-ACA nuclei has provided a range of potent β-lactam antibiotics.Development of other procedures for olefin synthesis has broadened the scope, with the preparation of a range of alkenyl-, cycloalkenyl- and arylvinyl-oxyiminoacetamidopenicillins and cephalosporins.
