1191284-76-0

Upstream product

• 1321970-11-9 3-(4-chlorophenyl)-1-[(6-chloro-3-pyridinyl)methyl]-1H-pyrazole-5-carboxylic acid 

Downstream Products

• 1191284-88-4 3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-N-(4-fluorophenethyl)-1H-pyrazole-5-carboxamide 
• 1191284-86-2 3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-N-phenethyl-1H-pyrazole-5-carboxamide 
• 1191284-89-5 3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-N-(2-fluorophenethyl)-1H-pyrazole-5-carboxamide 
• 1191284-87-3 3-(4-chlorophenyl)-1-((6-chloropyridin-3-yl)methyl)-N-(3-methoxyphenethyl)-1H-pyrazole-5-carboxamide 
• 1488425-84-8 {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}(4-phenylpiperazin-1-yl)methanone 
• 1488425-85-9 {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(2-fluorophenyl) piperazin-1-yl]methanone 
• 1488425-86-0 {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(4-fluorophenyl) piperazin-1-yl]methanone 
• 1488425-87-1 {3-(4-chlorophenyl)-1-[(6-chloropyridin-3-yl)methyl]-1H-pyrazol-5-yl}[4-(3-methoxyphenyl) piperazin-1-yl]methanone 

Relevant academic research and scientific papers

Synthesis and antifungal activity of novel (1-arylmethyl-3-aryl-1Hpyrazol- 5-yl)(4-arylpiperazin-1-yl)methanone derivatives

A series of novel (1-arylmethyl-3-aryl-1H-pyrazol-5-yl)(4-arylpiperazin-1- yl)methanone derivatives were synthesised. Preliminary study of the structure-activity relationship revealed that 4-chlorophenyl, 4-tert-butylphenyl, 4-fluorophenyl and 3-methoxyphenyl had a promising effect on the antifungal activity.

Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells

A series of novel 3-aryl-1-arylmethyl-1H-pyrazole-5-carboxamide derivatives 3a-l, were synthesized by the reaction of 3-aryl-1-arylmethyl-1H-pyrazole-5-carbonyl chloride with substituted amine in excellent yields. The compounds 3e-h could suppress A549 lu