119138-83-9

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 144036-66-8 C₂₀H₂₂O₆ 
• 144036-68-0 tert-Butyl-((3S,5R)-3,6-diazido-5-benzyloxymethoxy-hexyloxy)-dimethyl-silane 
• 119138-78-2 (E)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-but-2-enoic acid methyl ester 
• 123151-79-1 (2E)-4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]but-2-en-1-ol 
• 119138-81-7 [(S)-3-Azido-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butoxy]-tert-butyl-diphenyl-silane 
• 119138-80-6 (R)-4-(tert-Butyl-diphenyl-silanyloxy)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-2-ol 
• 119138-79-3 [(2S,3S)-3-((R)-2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-oxiranyl]-methanol 
• 144036-67-9 C₃₄H₄₄O₇Si 
• 144036-65-7 C₂₀H₂₂O₆ 
• 119138-82-8 (2R,4S)-1,4-Diazido-6-(tert-butyl-diphenyl-silanyloxy)-hexan-2-ol 

Downstream Products

• 119138-85-1 (3R,5R)-3,6-Diazido-5-benzyloxymethoxy-hexanoic acid 
• 119138-84-0 [N'-((3R,5R)-3,6-Diazido-5-benzyloxymethoxy-hexanoyl)-N-methyl-hydrazino]-acetic acid benzyl ester 
• 33404-78-3 negamycin 

Relevant academic research and scientific papers

An Application of Quinic acid to the Synthesis of Linear Homochiral Molecules: A Synthesis of (+)-Negamycin.

The use of quinic acid for the synthesis of linear molecules is demonstrated by an efficient stereoselective synthesis of the antibiotic (+)-negamycin.

ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-NEGAMYCIN

An efficient enantioselective total synthesis of the antibiotic (+)-negamycin is described, the absolute stereochemistry deriving from (R)-(+)-malic acid and subsequent use of the Sharpless asymmetric epoxidation reaction.