1191385-01-9Relevant academic research and scientific papers
Synthesis of the monomeric counterpart of marinomycin A
Amans, Dominique,Bareille, Laurianne,Bellosta, Veronique,Cossy, Janine
scheme or table, p. 7665 - 7674 (2010/01/15)
(Chemical Equation Presented) An efficient and highly convergent synthesis of the monomeric counterpart of the antitumor-antibiotic marine natural product marinomycin A was achieved by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo- and regioselective cross-metathesis to generate the (E)-configured C20-C21 double bond, and a Horner-Wadsworth-Emmons olefination followed by a Pd-catalyzed Stille cross-coupling to construct the tetraene moiety.
