1191385-19-9 Usage
Biological Activity
b-raf inhibitor 1 is an inhibitor of b-raf kinase with ic50 values of 0.31μm and 0.72μm for cell proliferation, respectively in a375 and hct116 [1].b-raf is important in signal transduction and some mutant b-raf occurs in cancer cells. the most common mutation of these is v600e, which makes b-raf kinase constitutively active. b-raf inhibitor 1 belongs to the type iia inhibitors and binds to the dfg-out atp-binding site of b-raf. the selectivity of b-raf inhibitor 1 is less than of other type inhibitors. besides mutant b-raf, it can also inhibit wild type b-raf and other tyrosine kinase. in cells with wild type b-raf, b-raf inhibitor 1 can activate the raf-mek-erk signaling pathway via raf dimerization. the preclinical toxicity test shows b-raf inhibitor 1 can induce hyperplasia in a mouse model [1, 2].
references
[1] wang x, kim j. conformation-specific effects of raf kinase inhibitors. j med chem. 2012 sep 13;55(17):7332-41.[2] smith al, demorin ff, paras na, huang q, petkus jk, doherty em, nixey t, kim jl, whittington da, epstein lf, lee mr, rose mj, babij c, fernando m, hess k, le q, beltran p, carnahan j. selective inhibitors of the mutant b-raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. j med chem. 2009 oct 22;52(20):6189-92.
Check Digit Verification of cas no
The CAS Registry Mumber 1191385-19-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,1,3,8 and 5 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1191385-19:
(9*1)+(8*1)+(7*9)+(6*1)+(5*3)+(4*8)+(3*5)+(2*1)+(1*9)=159
159 % 10 = 9
So 1191385-19-9 is a valid CAS Registry Number.
