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Omeprazole manufacturer with low price
Cas No: 119141-89-8
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
(R)-5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
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High purity Omeprazole in stock
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USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
OMEPRAZOLE
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Omeprazole low
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USD $ 1550.0-1600.0 / Kilogram 1 Kilogram 50 Kilogram/Month Career Henan Chemical Co Contact Supplier
1H-Benzimidazole,6-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-
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No Data No Data 5 Hangzhou J&H Chemical Co., Ltd. Contact Supplier
(R)-Omeprazole
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USD $ 10.0-10.0 / Gram 1 Gram 10000 Kilogram/Day Zhejiang J&C Biological Technology Co.,Limited Contact Supplier
Omeprazole2 CAS NO.119141-89-8 for sale
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119141-89-8
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119141-89-8 Usage

Uses

R-Form of Omeprazole. Gastric proton-pump inhibitor

Definition

ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has R configuration at the sulfur atom.
InChI:InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

119141-89-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-omeprazole

1.2 Other means of identification

Product number -
Other names LOSEC

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119141-89-8 SDS

119141-89-8Synthetic route

omeprazole sulfide
73590-85-9

omeprazole sulfide

(R)-omeprazole
119141-89-8

(R)-omeprazole

Conditions
ConditionsYield
With C68H72N4O10Ti2; dihydrogen peroxide In water; ethyl acetate at 0℃; for 24h; Reagent/catalyst; enantioselective reaction;93.5%
With N-methyl-6-aza-5β,6β-epoxy-cholestane-3β-tert-butyldiphenylsilyloxy tetrafluoroborate In dichloromethane at -70 - 20℃; for 3h; Inert atmosphere; enantioselective reaction;86%
With tert.-butylhydroperoxide In water; toluene at -20℃; for 12h;n/a
omeprazole
73590-58-6

omeprazole

(R)-omeprazole
119141-89-8

(R)-omeprazole

Conditions
ConditionsYield
enantiomeric resolution; inclusion complexation with (R)-(+)-2,2'-dihydroxy-1,1'-binaphthyl;
omeprazole sodium

omeprazole sodium

(R)-omeprazole
119141-89-8

(R)-omeprazole

Conditions
ConditionsYield
Stage #1: omeprazole sodium With diethyl (2S,3S)-tartrate; (S)-Mandelic acid; titanium(IV)isopropoxide; triethylamine In acetone at 35 - 40℃; for 0.25 - 0.5h;
Stage #2: With sodium hydrogencarbonate In dichloromethane for 0.25 - 0.5h;
omeprazole
73590-58-6

omeprazole

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With triethylamine In methanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate;
With N,N-dimethyl-ethanamine In ethanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate;
With N,N-dimethyl-ethanamine In methanol Purification / work up; Chiral supercritical fluid chromatography; Resolution of racemate;
1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole
1138242-22-4

1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole

(R)-omeprazole
119141-89-8

(R)-omeprazole

Conditions
ConditionsYield
Stage #1: 1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole; 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole; 1-(S)-camphor sulfonyl-6-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole; 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole With methanol at 25℃; for 0.5h;
Stage #2: With methanol; sodium hydroxide; water at 25℃; for 3.16667h;
Stage #3: With water; acetic acid In methanol pH=6.8;
omeprazole sulfide
73590-85-9

omeprazole sulfide

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
With 1,2:4,5-di-O-cyclohexylidene-D-fructopyranose; Cumene hydroperoxide; vanadium(V) oxytripropoxide; N-ethyl-N,N-diisopropylamine In water; ethyl acetate at 20 - 55℃; for 20.1667 - 20.25h; Product distribution / selectivity;
With Oxone; ethylenediaminetetraacetic acid; sodium hydrogencarbonate; 1,2:4,5-di-O-cyclohexylidene-β-D-erythro-hexo-2,3-diulopyranose In acetonitrile at -10 - 20℃; for 3.16667 - 3.25h; Product distribution / selectivity;
Stage #1: omeprazole sulfide With diethyl (2S,3S)-tartrate; titanium(IV) isopropylate In water; toluene at 55℃; for 1h;
Stage #2: With Cumene hydroperoxide In water; toluene at 30℃; for 4.5h; Further stages. Title compound not separated from byproducts.;
omeprazole sulfide
73590-85-9

omeprazole sulfide

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

omeprazole sulphone

omeprazole sulphone

C

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water at 20 - 70℃; for 1.5h; Heating / reflux;
Stage #2: With Cumene hydroperoxide In water at 20℃; Product distribution / selectivity;
Stage #1: omeprazole sulfide With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In dichloromethane; water at 20 - 70℃; for 1.5h; Heating / reflux;
Stage #2: With Cumene hydroperoxide In dichloromethane; water at 20℃; Product distribution / selectivity;
With dihydrogen peroxide; Mn-complex of (R,R)-1,2-bis(3,5-di-tert-butyl-2-hydroxybenzylamino)cyclohexane In water; acetonitrile at -10℃; for 5h; Product distribution / selectivity;A n/a
B n/a
C n/a
3C8H8O3*C8H14O6*C12H28O4Ti*C17H19N3O3S

3C8H8O3*C8H14O6*C12H28O4Ti*C17H19N3O3S

(R)-omeprazole
119141-89-8

(R)-omeprazole

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 20℃; for 0.5h; Product distribution / selectivity;
1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R/S)-sulfinyl]-1H-benzimidazole

1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R/S)-sulfinyl]-1H-benzimidazole

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: 1-(S)-camphor sulfonyl-5-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R/S)-sulfinyl]-1H-benzimidazole With water; sodium hydroxide at 25℃; for 6.5h;
Stage #2: With hydrogenchloride In dichloromethane; water pH=7.0; Product distribution / selectivity;
omeprazole sodium

omeprazole sodium

A

(R)-omeprazole
119141-89-8

(R)-omeprazole

B

esomeprazole
119141-88-7

esomeprazole

Conditions
ConditionsYield
Stage #1: omeprazole sodium With titanium(IV) isopropylate; diethyl (2S,3S)-tartrate; water; triethylamine In acetone at 35 - 40℃;
Stage #2: With (S)-Mandelic acid In acetone at 35 - 40℃; for 2h;
Stage #3: With sodium hydrogencarbonate In dichloromethane; water for 0.5h; Concentration;
A n/a
B n/a
(R)-omeprazole
119141-89-8

(R)-omeprazole

5-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt

5-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 0.5h;95%
With sodium hydroxide In methanol at 5 - 10℃; for 0.75 - 1.5h;
(R)-omeprazole
119141-89-8

(R)-omeprazole

(R)-esomeprazole potassium salt

(R)-esomeprazole potassium salt

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 0.5h; Product distribution / selectivity;94.1%
With potassium hydroxide In methanol at 5 - 10℃; for 0.75 - 1.5h;
(R)-omeprazole
119141-89-8

(R)-omeprazole

esomeprazole magnesium dihydrate

esomeprazole magnesium dihydrate

Conditions
ConditionsYield
With magnesium chloride In methanol; water at 20℃; for 0.5h;90%
chloromethyl (1R)-endo-(+)-fenchyl ether

chloromethyl (1R)-endo-(+)-fenchyl ether

(R)-omeprazole
119141-89-8

(R)-omeprazole

A

5-Methoxy-2-((R)-4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1-((1R,2R,4S)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yloxymethyl)-1H-benzoimidazole

5-Methoxy-2-((R)-4-methoxy-3,5-dimethyl-pyridin-2-ylmethanesulfinyl)-1-((1R,2R,4S)-1,3,3-trimethyl-bicyclo[2.2.1]hept-2-yloxymethyl)-1H-benzoimidazole

B

6-methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-(R)-sulfinyl}-1-({[(1R-endo)-1,3,3-trimethylbicyclo[2.2.1]hept-=2-yl]oxy}methyl)-1H-benzimidazole

6-methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-(R)-sulfinyl}-1-({[(1R-endo)-1,3,3-trimethylbicyclo[2.2.1]hept-=2-yl]oxy}methyl)-1H-benzimidazole

(R)-omeprazole
119141-89-8

(R)-omeprazole

(-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole magnesium

(-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole magnesium

Conditions
ConditionsYield
Stage #1: With magnesium In methanol; dichloromethane for 1 - 2h;
Stage #2: (R)-omeprazole In methanol; dichloromethane at 5 - 10℃; for 0.25 - 0.5h;
(R)-omeprazole
119141-89-8

(R)-omeprazole

magnesium R-omeprazole

magnesium R-omeprazole

Conditions
ConditionsYield
Stage #1: (R)-omeprazole With magnesium ethylate In methanol; ethanol for 48h;
Stage #2: With water In methanol for 1h;
(R)-omeprazole
119141-89-8

(R)-omeprazole

S-omeprazole magnesium

S-omeprazole magnesium

Conditions
ConditionsYield
With magnesium methanolate In methanol at 20℃; for 0.5h;n/a

119141-89-8Upstream product

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