1191445-85-8

Basic information

• Product Name: 2-chloro-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine
• Synonyms: 2-chloro-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine
• CAS NO: 1191445-85-8
• Molecular Weight: 308.69
• Mol File: 1191445-85-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine(1191445-85-8)
• EPA Substance Registry System: 2-chloro-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine(1191445-85-8)

Safety Data

• Hazardous Substances Data: 1191445-85-8(Hazardous Substances Data)

Upstream product

• 3038-47-9 2-(trifluoromethyl)phenylacetonitrile 
• 7521-41-7 2-Aminonicotinaldehyde 
• 1233246-24-6 3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-amine 

Downstream Products

• 1228431-91-1 C₁₅H₈F₃N₅ 
• 1246464-10-7 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine 

Relevant articles and documents

A facile greener synthesis, antimicrobial evaluation and molecular modelling of new 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-one derivatives

Abstract: The synthesis of 4-aryl-2-(3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridin-2-yl)phthalazin-1(2H)-ones was performed by cyclization of 2-hydrazinyl-3-(2-(trifluoromethyl)phenyl)-1,8-naphthyridine with 2-aroylbenzoic acids in ethanol containing a catalytic amount of concentrated sulfuric acid under solid state conditions. All these synthesized compounds (8a–h) were screened for their in vitro antibacterial activity against gram-positive bacteria such as (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli) and also evaluated for their antifungal activity against Aspergillus Niger and Helmenthosphorium oryzae fungal strains. Some of the products demonstrate good antibacterial activity and moderate antifungal activity. In predominantly, 8b, 8d, 8g, and 8h compounds showed good to excellent antibacterial and antifungal activities. The antimicrobial activity of the compound 8 was further investigated with the help of in LibDock score docking study to predict the active sites. Graphical abstract: [Figure not available: see fulltext.].

An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity

The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.