119183-52-7Relevant academic research and scientific papers
Transition Metal Catalyzed Grignard Cross-Coupling to Ortho-Halogenated Aryl Imines. An Efficient Synthesis of Ortho-Substituted Aryl Aldehydes
Pridgen, N. Lendon,Snyder, L.,Prol, J.
, p. 1523 - 1526 (1989)
N-(o-Halogenated benzylidene)cyclohexylamines 2 were successfully reacted with reducing and nonreducing Grignard reagents in a transition metal catalyzed cross-coupling reaction resulting in an efficient single-step synthesis of ortho-substituted benzaldehydes after acidic workup.The dihalogenated benzylidene amines reacted regioselectively at the amine-activated ortho position to yield ortho-substituted halogenated benzaldehydes.
