1191908-07-2Relevant academic research and scientific papers
Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-g
Sakauchi, Nobuki,Kohara, Yasuhisa,Sato, Ayumu,Suzaki, Tomohiko,Imai, Yumi,Okabe, Yuichi,Imai, Shigemitsu,Saikawa, Reiko,Nagabukuro, Hiroshi,Kuno, Haruhiko,Fujita, Hisashi,Kamo, Izumi,Yoshida, Masato
, p. 2989 - 3002 (2016/05/19)
A novel structural class of iminopyridine derivative 1 was identified as a potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonist against α1A- and α1B-AR through scre
IMINOPYRIDINE DERIVATIVE AND USE THEREOF
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Page/Page column 42, (2011/01/12)
The present invention aims to provide a compound having a superior selective α1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like.The present invention provides a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.The present invention aims to provide a compound having a superior selective ± 1D adrenergic receptor antagonistic action and useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like. The present invention provides a compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.
