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1-(((pyridin-2-yl)acetyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea is a complex organic compound characterized by its molecular structure that features a urea group, a piperidine ring, a pyridine ring, and a trifluoromethoxyphenyl group. 1-(((pyridin-2-yl)acetyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea is synthesized through a series of chemical reactions involving pyridine-2-ylacetyl chloride, piperidin-4-ol, and 4-(trifluoromethoxy)aniline. Its unique structural features and the presence of functional groups make it a promising candidate for pharmaceutical research and drug development, as they can potentially interact with various biological targets.

1191908-87-8

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1191908-87-8 Usage

Uses

Used in Pharmaceutical Research:
1-(((pyridin-2-yl)acetyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea is used as a research compound for exploring its potential interactions with biological targets. The presence of the urea group, piperidine ring, and pyridine ring in its structure may allow it to bind with specific receptors or enzymes, making it a valuable tool in the development of new drugs.
Used in Drug Development:
In the pharmaceutical industry, 1-(((pyridin-2-yl)acetyl)piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea is used as a lead compound in the development of new therapeutic agents. Its structural features and functional groups can be further modified and optimized to enhance its pharmacological properties, potentially leading to the creation of novel drugs with improved efficacy and safety profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 1191908-87-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,1,9,0 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1191908-87:
(9*1)+(8*1)+(7*9)+(6*1)+(5*9)+(4*0)+(3*8)+(2*8)+(1*7)=178
178 % 10 = 8
So 1191908-87-8 is a valid CAS Registry Number.

1191908-87-8Upstream product

1191908-87-8Downstream Products

1191908-87-8Relevant academic research and scientific papers

1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: Structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain

Rose, Tristan E.,Morisseau, Christophe,Liu, Jun-Yan,Inceoglu, Bora,Jones, Paul D.,Sanborn, James R.,Hammock, Bruce D.

supporting information; experimental part, p. 7067 - 7075 (2010/12/25)

1,3-Disubstituted ureas possessing a piperidyl moiety have been synthesized to investigate their structure-activity relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. For example, 1-(1-(cyclopropanecarbonyl) piperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (52) showed a 7-fold increase in potency, a 65-fold increase in Cmax, and a 3300-fold increase in AUC over its adamantane analogue 1-(1-adamantyl)-3-(1-propionylpiperidin-4-yl) urea (2). This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.

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