1191911-26-8 Usage
Description
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide is a complex organic compound characterized by its unique molecular structure. It is a derivative of pyrimidines, which are known for their diverse range of biological activities and potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide is used as a potential therapeutic agent for various diseases due to its unique chemical properties and interactions with biological targets.
Used in Parkinson's Disease Treatment:
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide is used as an inhibitor of LRRK2, a protein that plays a role in the expression of Parkinson's disease. It acts as an ATP-competitive inhibitor, targeting the LRRK2G2019S mutant linked to neurotoxicity and Parkinson's disease, potentially reducing cell injury in affected neurons.
Used in Drug Design and Development:
The compound's specific interactions with biological targets make it a valuable candidate for drug design and development. Researchers can use its structure as a starting point to develop new drugs with improved efficacy and selectivity for treating various diseases.
Used in Research and Development:
N-(2-(2-(2-Methoxy-4-MorpholinophenylaMino)-5-fluoropyriMidin-4-ylaMino)phenyl)MethanesulfonaMide can be utilized in research and development to study the underlying mechanisms of diseases and to develop targeted therapies. Its unique chemical properties allow for the exploration of novel approaches to drug discovery and the potential to create more effective treatments.
references
[1] ramsden n, perrin j, ren z, et al. chemoproteomics-based design of potent lrrk2-selective lead compounds that attenuate parkinson’s disease-related toxicity in human neurons. acs chemical biology, 2011, 6(10): 1021-1028.[2] troxler t, greenidge p, zimmermann k, et al. discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of lrrk2. bioorganic & medicinal chemistry letters, 2013, 23(14): 4085-4090.
Check Digit Verification of cas no
The CAS Registry Mumber 1191911-26-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,1,9,1 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1191911-26:
(9*1)+(8*1)+(7*9)+(6*1)+(5*9)+(4*1)+(3*1)+(2*2)+(1*6)=148
148 % 10 = 8
So 1191911-26-8 is a valid CAS Registry Number.