1191923-19-9Relevant articles and documents
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors
Heim-Riether, Alexander,Taylor, Steven J.,Liang, Shuang,Gao, Donghong Amy,Xiong, Zhaoming,Michael August,Collins, Brandon K.,Farmer II, Bennett T.,Haverty, Kathleen,Hill-Drzewi, Melissa,Junker, Hans-Dieter,Mariana Margarit,Moss, Neil,Neumann, Thomas,Proudfoot, John R.,Keenan, Lana Smith,Sekul, Renate,Zhang, Qiang,Li, Jun,Farrow, Neil A.
scheme or table, p. 5321 - 5324 (2010/05/02)
Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13 inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was observed to have a binding mode distinct from previously published MMP-1