1191923-56-4Relevant articles and documents
A practical synthesis of m-prostaglandin E synthase-1 inhibitor MK-7285
Gosselin, Francis,Lau, Stephen,Nadeau, Christian,Trinh, Thao,O'Shea, Paul D.,Davies, Ian W.
supporting information; experimental part, p. 7790 - 7797 (2010/03/05)
(Chemical Equation Presented) A practical, kilogram-scale chromatography-free synthesis of mPGE synthase I inhibitor MK-7285 is described. The route features a convergent assembly of the core phenanthrene unit via amide-directed ortho-metalation and proxi