1191998-74-9Relevant academic research and scientific papers
Stereoselective synthesis of (E)-?-aryloxyl and alkyloxyl acrylates through DABCO-catalysed Michael additions of phenols and alcohols to ethyl 2,3-butadienoate
Wei, Feng,Haibo, Wu,Houjun, Qian,Zhengyi, Li,Xiaoqiang, Sun,Zhiming, Wang
, p. 364 - 367 (2016/07/06)
The development of DABCO-catalysed Michael addition of phenols and alcohols to ethyl 2,3-butadienoate provides an efficient synthetic pathway to (E)-?-aryloxyl and alkyloxyl acrylates in i-PrOH or under solvent-free conditions. The major advantages of the present method are wide substrate scope, mild reaction conditions, high stereoselectivity, and good reaction yields.
Enantioselective synthesis of β-aryloxycarboxylic esters via asymmetric hydrogenation of β-aryloxy-α,β-unsaturated esters
Stewart, Gavin W.,Yamagata, Adam D. Gammack,Gibson, Andrew W.,Keen, Stephen P.,Scott, Jeremy P.,Shevlin, Michael
supporting information, p. 5440 - 5443,4 (2012/12/12)
A novel synthesis of β-aryloxycarboxylic esters via asymmetric hydrogenation of the corresponding β-aryloxy-α,β-unsaturated esters has been demonstrated. Bis(norbornadiene)rhodium(I) tetrafluoroborate (1 mol %) and Walphos W008-1 were used to generate the
PYRROLIDINONE GLUCOKINASE ACTIVATORS
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Page/Page column 96, (2009/10/30)
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
