1192-17-2

Usage

Uses

Used in Chemical Synthesis:
2,2-diethyloxirane is used as an intermediate in the synthesis of other organic compounds, playing a crucial role in the production of various chemical products.
Used as a Solvent:
In the chemical industry, 2,2-diethyloxirane is utilized as a solvent for specific applications, taking advantage of its unique solvency properties.
Used in Polymer Production:
2,2-diethyloxirane serves as a monomer in the production of polymer materials, contributing to the creation of a range of polymeric substances with diverse applications.
Used in the Paint and Coating Industry:
2,2-diethyloxirane is used as a component in the formulation of paints and coatings, enhancing their properties and performance.
Used in the Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, given its role in chemical synthesis, 2,2-diethyloxirane may also be utilized in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients or excipients.

Upstream product

• 15642-93-0 3-chloromethyl-pentan-3-ol 
• 760-21-4 2-ethyl-1-butene 

Downstream Products

• 2051-32-3 3-ethyl-3-octanol 
• 597-49-9 3-ethylpentan-3-ol 
• 34577-40-7 3-benzyl-3-pentanol 
• 597-76-2 3-ethyl-3-hexanol 
• 1907-46-6 3-ethyl-5-hexen-3-ol 
• 91328-44-8 3-ethyl-5-methylheptan-3-ol 
• 97-95-0 2-ethyl-1-butanol 
• 1141779-97-6 3-((3-bromophenoxy)methyl)pentan-3-ol 

Relevant academic research and scientific papers

Molybdenum containing surface complex for olefin epoxidation

Silica-supported molybdenum surface complexes were prepared by the reaction between (N≡)Mo(OtBu)3 and silica via displacement of the tert-butoxy ligands for siloxyls from the silica surface. The structure of the surface molybdenum complexes was well defined by in-situ FT-IR, elemental analysis, 1H NMR and 13C CP/MAS NMR techniques. The surface complexes could undergo alcoholysis reaction with CD3OD and CH3OH in the same way as free (N≡)Mo(OtBu)3 and they show high catalytic activity and selectivity in olefin epoxidation. Initial rates up to 24.9 mmol epoxide (mmol Mo)-1 min-1 were achieved in the epoxidation of cyclohexene using TBHP as oxidant.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Regioselective Carbonylation of 2,2-Disubstituted Epoxides: An Alternative Route to Ketone-Based Aldol Products

We report the regioselective carbonylation of 2,2-disubstituted epoxides to β,β-disubstituted β-lactones. Mechanistic studies revealed epoxide ring-opening as the turnover limiting step, an insight that facilitated the development of improved reaction conditions using weakly donating, ethereal solvents. A wide range of epoxides can be carbonylated to β-lactones, which are subsequently ring-opened to produce ketone-based aldol adducts, providing an alternative to the Mukaiyama aldol reaction. Enantiopure epoxides were demonstrated to undergo the carbonylation/ring-opening process with retention of stereochemistry to form enantiopure β-hydroxy esters.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

AMIDE DERIVATIVES FOR GPR119 AGONIST

The present invention relates to novel amide derivatives, stereoisomers thereof or pharmaceutically acceptable salts thereof; methods for preparing the compound; and pharmaceutical compositions comprising the compound. The novel amide derivatives, according to the present invention, having an effect as GPR119 agonist can be used for treatment of metabolic disorders, including diabetes mellitus (especially type II) and related disorders.

2-(2-Oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents

From a fungicidal screen, we identified 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as fungicidal agents against Candida species, additionally characterized by antifungal activity against Aspergillus species. However, development of this series was hampered by low plasmatic stability. Introduction of a gem-dimethyl on the 6-position of the morpholin-2-one core led to considerable improvement in plasmatic stability while maintaining in vitro antifungal activity. Further optimization of the series resulted in the discovery of N-(biphenyl-3-ylmethyl)-2-(4-ethyl-6,6-dimethyl-2-oxomorpholin-3-yl)acetamide (87), which, in addition to fungicidal activity against Candida species, shows promising and broad antifungal in vitro activity against various fungi species, such as molds and dermatophytes. In vivo efficacy was also demonstrated in a murine model of systemic Candida albicans infection with a significant fungal load reduction in kidneys.

PIPERIDINE DERIVATIVES FOR GPR119 AGONIST

The present invention relates to novel piperidine derivatives, stereoisomers thereof or pharmaceutically acceptable salts thereof; methods for preparing the compound; and pharmaceutical compositions comprising the compound. The novel piperidine derivatives, according to the present invention, having an effect as GPR119 agonist can be used for treatment of metabolic disorders, including diabetes mellitus (especially type II) and related disorders.

ANTIFUNGAL COMPOUNDS

The present invention relates to a series of novel compounds which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparation, pharmaceutical compositions comprising them and to the compounds for use as a medicament, more in particular antifungal medicament.

ANTIFUNGAL COMPOUNDS

The present invention relates to a series of novel compounds which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparation, pharmaceutical compositions comprising them and to the compounds for use as a medicament, more in particular antifungal medicament.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF

The present invention relates to thiazolidinylidene containing compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, and X are as defined in the specification, compositions comprising su