1192036-03-5

Basic information

• Product Name: (E)-methyl 6-((3,4-difluorophenyl)(ethoxyimino)methyl)nicotinate
• Synonyms: (E)-methyl 6-((3,4-difluorophenyl)(ethoxyimino)methyl)nicotinate
• CAS NO: 1192036-03-5
• Molecular Weight: 320.296
• Mol File: 1192036-03-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-methyl 6-((3,4-difluorophenyl)(ethoxyimino)methyl)nicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 6-((3,4-difluorophenyl)(ethoxyimino)methyl)nicotinate(1192036-03-5)
• EPA Substance Registry System: (E)-methyl 6-((3,4-difluorophenyl)(ethoxyimino)methyl)nicotinate(1192036-03-5)

Safety Data

• Hazardous Substances Data: 1192036-03-5(Hazardous Substances Data)

Upstream product

• 10165-86-3 methyl 6-formylpyridine-3-carboxylate 
• 64248-58-4 1,2-difluoro-4-iodo-benzene 
• 1192036-02-4 C₁₀H₁₁BrN₂O₃ 
• 168267-41-2 (3,4-difluorophenyl)boronic acid 

Downstream Products

• 1017599-32-4 (E)-(3,4-difluorophenyl)[5-(hydroxymethyl)pyridine-2-yl]methanone O-ethyloxime 

Relevant articles and documents

Palladium-Catalyzed Arylation of (Di)azinyl Aldoxime Ethers by Aryl Iodides: Stereoselective Synthesis of Unsymmetrical (E)-(Di)azinylaryl Ketoxime Ethers

The first example of direct arylation of (di)azinyl aldoxime ethers by aryl iodides is reported. The reaction produces, in a single step, a variety of geometrically pure unsymmetrical (E)-(di)azinylaryl ketoxime ethers, a class of nitrogenated motifs that have found wide applications in medicinal and organic chemistry but are difficult to access using conventional procedure. The utility of the method is further illustrated in a formal synthesis of the Merck melanin-concentrating hormone, 1 receptor antagonist. Arylationship of convenience: Direct arylation of (di)azinyl aldoxime ethers by aryl iodides produces, in a single step, a variety of geometrically pure unsymmetrical (E)-(di)azinylaryl ketoxime ethers (see scheme), a class of nitrogenated motifs that have found wide application in medicinal and organic chemistry but are difficult to access by conventional procedures.