1192108-48-7Relevant academic research and scientific papers
Endowing indole-based tubulin inhibitors with an anchor for derivatization: Highly potent 3-substituted indolephenstatins and indoleisocombretastatins
álvarez, Raquel,Puebla, Pilar,Díaz, J. Fernando,Bento, Ana C.,García-Navas, Rósula,De La Iglesia-Vicente, Janis,Mollinedo, Faustino,Andreu, José Manuel,Medarde, Manuel,Peláez, Rafael
supporting information, p. 2813 - 2827 (2013/06/04)
Colchicine site ligands with indole B rings are potent tubulin polymerization inhibitors. Structural modifications at the indole 3-position of 1-methyl-5-indolyl-based isocombretastatins (1,1-diarylethenes) and phenstatins endowed them with anchors for fu
Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins
álvarez, Concepción,álvarez, Raquel,Corchete, Purificación,Pérez-Melero, Concepción,Peláez, Rafael,Medarde, Manuel
experimental part, p. 588 - 597 (2010/04/26)
A new family of phenstatin analogues has been synthesized and assayed. This family simultaneously incorporates modifications of the A-ring (replacement of the 3,4,5-trimethoxyphenyl by the 2,3,4-trimethoxyphenyl arrangement), B-ring (N-alkyl-5-indolyl) and conversion of the Oxygen keto group into a substituted nitrogen (oximes, hydrazones, and their acetylderivatives). The conjunction of all this changes greatly diminishes the antimitotic and antiproliferative activities, but the maintenance of the keto bridge produces a potent analogue with the unusual 2,3,4-trimethoxyphenyl moiety.
Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds
Alvarez, Raquel,Alvarez, Concepcion,Mollinedo, Faustino,Sierra, Beatriz G.,Medarde, Manuel,Pelaez, Rafael
experimental part, p. 6422 - 6431 (2011/02/24)
Isocombretastatins A are 1,1-diarylethene isomers of combretastatins A. We have synthesized the isomers of combretastatin A-4, deoxycombretastatin A-4, 3-amino-deoxycombretastatin A-4 (AVE-8063), naphthylcombretastatin and the N-methyl- and N-ethyl-5-indo
