1192136-23-4Relevant academic research and scientific papers
Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
Goodwin, Nicole C.,Mabon, Ross,Harrison, Bryce A.,Shadoan, Melanie K.,Almstead, Zheng Y.,Xie, Yiling,Healy, Jason,Buhring, Lindsey M.,DaCosta, Christopher M.,Bardenhagen, Jennifer,Mseeh, Faika,Liu, Qingyun,Nouraldeen, Amr,Wilson, Alan G. E.,Kimball, S. David,Powell, David R.,Rawlins, David B.
, p. 6201 - 6204 (2009)
The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo. 2009 American Chemical Society.
