1192142-11-2

Upstream product

• 1187832-23-0 (3R)-2-(tert-butoxycarbonyl)-7-methoxy-3-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 220122-59-8 N-<(2'S)-amino-3'-methylbutyl>-(3R,4R)-4-(3-hydroxyphenyl)piperidine 

Downstream Products

• 1187884-31-6 RTI-5989-240 
• 1187884-33-8 (3R)-7-methoxy-N-{[(1S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl]-(2-methylpropyl)}-3-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 

Relevant academic research and scientific papers

KAPPA OPIOID RECEPTOR LIGANDS

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid

Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3- hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3, 4-tetrahydro-3-isoquinolinecarboxamide (JDTic

In previous structure-activity relationship (SAR) studies, (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide (JDTic, 3) was identified as the first pote