1192159-85-5Relevant academic research and scientific papers
Nickel-catalyzed, base-mediated amination/hydroamination reaction sequence for a modular synthesis of indoles
Ackermann, Lutz,Song, Weifeng,Sandmann, René
, p. 195 - 201 (2011)
A catalytic system consisting of [Ni(cod)2] and ligand dppf enabled an efficient synthesis of differently substituted indoles through a modular reaction sequence, which consists of intermolecular aminations and intramolecular hydroaminations with ortho-alkynylhaloarenes.
Copper-catalyzed N-arylation/hydroamin(d)ation domino synthesis of indoles and its application to the preparation of a Chekl/KDR kinase inhibitor pharmacophore
Ackermann, Lutz,Barfuesser, Sebastian,Potukuchi, Harish K.
supporting information; experimental part, p. 1064 - 1072 (2010/03/03)
Inexpensive copper catalysts allow for efficient syntheses of N-aryl-, N-acyl-, or N-H-(aza)in-doles starting from ortho-alkynylbromoarenes. The broad scope of this domino N-arylation/hydro-amin(d)ation process is highlighted by the synthesis of highly fu
