1192159-95-7Relevant articles and documents
Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes
Makida, Yusuke,Saita, Masahiro,Kuramoto, Takahiro,Ishizuka, Kentaro,Kuwano, Ryoichi
supporting information, p. 11859 - 11862 (2016/11/16)
High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.
Copper-catalyzed N-arylation/hydroamin(d)ation domino synthesis of indoles and its application to the preparation of a Chekl/KDR kinase inhibitor pharmacophore
Ackermann, Lutz,Barfuesser, Sebastian,Potukuchi, Harish K.
supporting information; experimental part, p. 1064 - 1072 (2010/03/03)
Inexpensive copper catalysts allow for efficient syntheses of N-aryl-, N-acyl-, or N-H-(aza)in-doles starting from ortho-alkynylbromoarenes. The broad scope of this domino N-arylation/hydro-amin(d)ation process is highlighted by the synthesis of highly fu