1192167-41-1

Basic information

• Product Name: 1-(4-fluorophenyl)-1,3-diphenyl-2-propyn-1-ol
• Synonyms: 1-(4-fluorophenyl)-1,3-diphenyl-2-propyn-1-ol
• CAS NO: 1192167-41-1
• Molecular Weight: 302.348
• Mol File: 1192167-41-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-1,3-diphenyl-2-propyn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-1,3-diphenyl-2-propyn-1-ol(1192167-41-1)
• EPA Substance Registry System: 1-(4-fluorophenyl)-1,3-diphenyl-2-propyn-1-ol(1192167-41-1)

Safety Data

• Hazardous Substances Data: 1192167-41-1(Hazardous Substances Data)

Upstream product

• 345-83-5 4-fluorobenzophenone 
• 536-74-3 phenylacetylene 
• 149099-27-4 4-fluorobenzhydrol 

Downstream Products

• 1192167-45-5 1-(4-fluorophenyl)-5,7-dimethyl-1,3-diphenyl-1H-inden-6-ol 
• 1263098-37-8 4-((4-fluorophenyl)(phenyl)methyl)-2,5-diphenyloxazole 

Relevant articles and documents

Lewis Acid-Catalyzed Formal [3+3] Annulation of Propargylic Alcohols with 4-Hydroxy-2H-chromen-2-ones

A Lewis acid-catalyzed formal [3+3] cascade annulation strategy for the formation of diverse tricyclic compounds possessing functionalized pyrano[3,2-c]chromen-5(2H)-one fragments has been developed using propargylic alcohols and 4-hydroxy-2H-chromen-2-on

Synthesis of 1H-Pyrrolo[1,2-a]indoles via Lewis Acid-Catalyzed Annulation of Propargylic Alcohols with 2-Ethynylanilines

A novel highly efficient, environmentally benign Lewis acid-catalyzed, and protection-free protocol for the construction of valuable polycyclic products bearing a 1H-pyrrolo[1,2-a]indole scaffold is described, starting from readily available propargylic alcohols and 2-ethynylanilines. The one-pot transformation entails the cleavage of one C?O bond, and the construction of two C?N bonds and one C?C double bond. This unique operationally simple method is performed under mild conditions and in air, producing water as the only byproduct; it is scalable and demonstrates good functional group compatibility and broad scope.

In Situ Generation of Allenes and their Application to One-Pot Assembly of Functionalized Fluoreno[3,2-b]furans by Calcium-Catalyzed, Regioselective, 3-Component Reactions

We have developed a novel synthetic methodology for the preparation of tetra-annulated fluorenofurans and fluorenopyrans using calcium(II)-catalyzed one-pot, three-component reaction. In this reaction, tert-propargyl alcohols react with 1,3-dicarbonyls to form tetra-substituted allenes, which are subsequently undergoing regiodivergent annulation with sec-propargyl alcohols to produce the fluorene-fused furan compounds. Broad substrate scope, regioselectivity, gram-scale synthesis, and benzylic functionalization of products are some of the highlights of this protocol.