1192176-41-2

Upstream product

• 629-41-4 1,8-Octanediol 
• 85118-01-0 alpha-bromo-3,4-difluorotoluene 

Downstream Products

• 1192176-42-3 8-(3,4-difluoro-benzyloxy)-octanoic acid 
• 1192176-43-4 (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid benzyl ester 
• 1192177-66-4 (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-trimethylammonio-butyrate 
• 1192176-40-1 (R)-3-[8-(3,4-difluoro-benzyloxy)-octanoylamino]-4-dimethylamino-butyric acid 

Relevant academic research and scientific papers

4-DIMETHYLAMINOBUTYRIC ACID DERIVATIVES

This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula wherein A1, A2, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.

4-TRIMETHYLAMMONIO-BUTYRATES AS CPT2 INHIBITORS

This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.