119219-87-3Relevant academic research and scientific papers
Palladium(II) catalyst systems for the addition of boronic acids to bicyclic alkenes: New scope and reactivity
Lautens, Mark,Dockendorff, Chris
, p. 3695 - 3698 (2003)
(Matrix presented) The palladium-catalyzed ring-opening addition of arylboronic acids to heterobicyclic alkenes is reported. Excellent yields are obtained for the addition of a wide variety of arylboronic acids to aza- and oxabicyclic alkenes. This methodology is especially useful in the synthesis of 1-amino-2-aryldihydronaphthalene scaffolds, for which rhodium catalysts are currently unreactive or give complex mixtures. Asymmetric versions of these reactions are under development, and preliminary results are reported.
