1192217-80-3Relevant academic research and scientific papers
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: Unique effects of the axial chirality on the selectivity of protein kinases inhibition
Yoshida, Kenyu,Itoyama, Ryosuke,Yamahira, Masashi,Tanaka, Junji,Loa?c, Nadège,Lozach, Olivier,Durieu, Emilie,Fukuda, Tsutomu,Ishibashi, Fumito,Meijer, Laurent,Iwao, Masatomo
, p. 7289 - 7301 (2013/10/21)
The total synthesis of the optically active (aR)- and (aS)-16- methyllamellarins N (3a and 3b) was achieved via resolution on HPLC chiral stationary phase. The kinase inhibitory activities of both enantiomers were evaluated on eight protein kinases releva
Design and synthesis of lamellarin D analogues targeting topoisomerase I
Ohta, Takeshi,Fukuda, Tsutomu,Ishibashi, Fumito,Iwao, Masatomo
supporting information; experimental part, p. 8143 - 8153 (2010/02/17)
(Chemical Equation Presented) A general synthetic route to rationally designed lamellarinDanalogues, 1-dearyllamellarinD(1) and 1-substituted 1-dearyllamellarin D (2), has been developed. The key pentacyclic intermediate 22 was prepared by palladium-catalyzed direct arylation of 12, which in turn was synthesized via C-2-selective lithiation of 15 followed by palladium-catalyzed cross-coupling as the key reactions. Compound 22 was converted to a wide range of C-1-substituted analogues 2 via regioselective electrophilic substitution and palladium-catalyzed cross-coupling reactions.
