1192217-80-3Relevant articles and documents
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: Unique effects of the axial chirality on the selectivity of protein kinases inhibition
Yoshida, Kenyu,Itoyama, Ryosuke,Yamahira, Masashi,Tanaka, Junji,Loa?c, Nadège,Lozach, Olivier,Durieu, Emilie,Fukuda, Tsutomu,Ishibashi, Fumito,Meijer, Laurent,Iwao, Masatomo
, p. 7289 - 7301 (2013/10/21)
The total synthesis of the optically active (aR)- and (aS)-16- methyllamellarins N (3a and 3b) was achieved via resolution on HPLC chiral stationary phase. The kinase inhibitory activities of both enantiomers were evaluated on eight protein kinases releva