1192264-55-3Relevant academic research and scientific papers
Synthesis and characterization of 2′-C-Me branched C-nucleosides as HCV polymerase inhibitors
Cho, Aesop,Zhang, Lijun,Xu, Jie,Babusis, Darius,Butler, Thomas,Lee, Rick,Saunders, Oliver L.,Wang, Ting,Parrish, Jay,Perry, Jason,Feng, Joy Y.,Ray, Adrian S.,Kim, Choung U.
, p. 4127 - 4132 (2012/07/14)
A series of 2′-C-methyl branched purine and pyrimidine C-nucleosides were prepared. Their anti-HCV activity and pharmacological properties were profiled, and compared with known 2′-C-Me N-nucleoside counterparts. In particular, 2′-C-Me 4-aza-7,9-dideazaad
CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
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Page/Page column 104; 105, (2009/12/05)
Provided are imidazol [1,5-f] [1,2.4]triazinyl, imidazol [1,2,4]triazinyl, and [1,2,4] triazolo [4,3-f] [1,2,4] triazinyl nucleosides of formula I nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections. Wherein X1 or X2 is indepently C-R10 or N and wherein at least one of X1 or X2 is N.
