1192322-77-2Relevant academic research and scientific papers
A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives
Min, Kyung Hoon,Xia, Yan,Kim, Eun Kyung,Jin, Yinglan,Kaur, Navneet,Kim, Eun Seon,Kim, Dae Kyong,Jung, Hwa Young,Choi, Yongseok,Park, Mi-Kyung,Min, Yong Ki,Lee, Kiho,Lee, Kyeong
scheme or table, p. 5376 - 5379 (2010/05/19)
Novel disubstituted adamantyl derivatives were synthesized and evaluated in a P-glycoprotein dependent multidrug resistance cancer cell line. The hit to lead optimization provided potent MDR reversal agents. Some potent adamantyl derivatives were more than 10-fold more potent than verapamil without considerable intrinsic cytotoxicity. The 3-trifluorophenyl derivative 14f did not affect the metabolism of CYP450 3A4, whereas most of MDR revertants had a weak inhibitory effect.
