119233-39-5Relevant articles and documents
PYRROLOTRIAZINE DERIVATIVES FOR TREATING KIT- AND PDGFRA-MEDIATED DISEASES
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Paragraph 00191-00192, (2020/10/21)
The present disclosure provides compounds of Formula I, pharmaceutical salts thereof, and/or solvates of any of the foregoing which are useful for treating diseases and conditions related to mutant KIT and PDGFRa and present an advantageously non-brain pe
Double-hetero atom six-membered ring of synthetic method
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, (2018/07/30)
The invention provides a double-hetero atom six-membered ring of synthetic method. The synthetic method comprises to alkyl substituted cyclopropane and benzyl alcohol and/or a the oxygen radical animal pen is mellow as the starting material, sequentially carry out the ring-opening reaction, a transesterification reaction, 1st sulfonylation reaction, alcoholysis reaction and the nucleophilic substitution reaction, catalytic hydrogenation reaction and 2nd sulfonylation reaction and forming ring reaction, to obtain the required double-hetero atom six-membered ring, a formula (1) of the structure shown. In order to price the comparatively cheap racemic alkyl substituted cyclopropane as raw materials, to participate in the ring-opening reaction, to obtain a ring opening product. Then under the action of the esterase, make the ring-opening products which is a transesterification reaction, disposable obtain the desired racemic compound. This avoids the traditional method of multi-step separation and purification in the synthesis step, shortens the synthetic route. In the above synthetic route also avoids the need to use some dangerous reagent, process more security, reducing waste generation, and save the process cost.
Synthesis of perfluorinated carboxylic acid membrane monomers by utilizing liquid-phase direct fluorination
Okazoe, Takashi,Watanabe, Kunio,Itoh, Masahiro,Shirakawa, Daisuke,Kawahara, Kengo,Tatematsu, Shin
, p. 521 - 527 (2007/10/03)
A new synthetic procedure for the preparation of perfluorinated carboxylic acid membrane monomers from non-fluorinated compounds has been developed. A key step in the synthetic route is liquid-phase direct fluorination reaction with elemental fluorine. Direct fluorination of a partially fluorinated diester, which was prepared from a hydrocarbon diol and a perfluorinated acyl fluoride, followed by thermal elimination, gave a perfluorinated diacyl fluoride, which is a precursor of a perfluorinated carboxylic acid membrane monomer.
Synthesis of novel acridino- and phenazino-18-crown-6 ligands and their optically pure dimethyl-substituted analogues for molecular recognition studies
Huszthy, Peter,Samu, Erika,Vermes, Borbala,Mezey-Vandor, Gabriella,Nogradi, Mihaly,Bradshaw, Jerald S.,Izatt, Reed M.
, p. 1491 - 1504 (2007/10/03)
Novel acridino- and phenazino-18-crown-6 ligands 5 and 6 were prepared from acridine-4.5-diol (9) and phenazine-1,9-diol (10) with tetraethylene glycol di-p-tosylate (11) using potassium tert-butoxide as a base in THF. New optically pure dimethyl-substitu
1,2-propanediol derivative
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, (2008/06/13)
An optically active compound particularly useful as a component of liquid crystal compositions having a high response rate and a chiral liquid crystal composition containing the same are provided, which optically active compound is expressed by the formul
A new synthesis of (S)-β-methyl-γ-butyrolactone and (S)-4-benzyloxy-3-methylbutanoic acid
Berens,Scharf
, p. 832 - 834 (2007/10/02)
A stereoselective synthesis of (S)-β-methyl-γ-butyrolactone [(S)-4,5-dihydro-4-methyl-2(3H)-furanone, 1] and of (S)-4-benzyloxy-3-methylbutanoic acid (2) is described. Both compounds are prepared starting from inexpensive L-ethyl lactate with overall yields of 26% and 30%, respectively. The products are valuable chiral building blocks.
